WNT10B Gene Summary [Human]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
WNT10B
Official Name
Wnt family member 10B [Source:HGNC Symbol;Acc:HGNC:12775]
Ensembl ID
ENSG00000169884
Bio databases IDs NCBI: 7480 Ensembl: ENSG00000169884
Aliases Wnt family member 10B
Synonyms SHFM6, STHAG8, wingless-type MMTV integration site family, member 10B, WNT-12, Wnt family member 10B
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human WNT10B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Wnt
  • wnt family
  • protein binding
  • receptor binding
  • found in Wnt-1

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • rheumatoid arthritis
  • osteoarthritis
  • lung adenocarcinoma formation
  • obesity
  • split-hand/foot malformation type 6
  • tumorigenesis
  • androgenic alopecia
  • Parkinson disease
  • diabetic nephropathy
  • squamous cell lung cancer
regulated by
regulates
role in cell
  • expression in
  • growth
  • apoptosis
  • quantity
  • proliferation
  • migration
  • development
  • differentiation
  • cell cycle progression
  • maturation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • extracellular matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human WNT10B gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • fungiform papilla development
  • chondrocyte differentiation
  • transcription from RNA polymerase II promoter
  • fat cell differentiation
  • positive regulation of osteoblast differentiation
  • bone trabecula formation
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of anagen
  • G2/M transition of mitotic cell cycle
  • skeletal muscle fiber development
  • cellular response to parathyroid hormone stimulus
  • regulation of skeletal muscle tissue development
  • osteoblast differentiation
  • canonical Wnt receptor signaling pathway
  • myoblast cell differentiation involved in skeletal muscle regeneration
  • positive regulation of bone mineralization
  • positive regulation of G2/M transition of mitotic cell cycle
  • sensory perception of taste
  • neuron differentiation
  • negative regulation of fat cell differentiation
  • positive regulation of canonical Wnt receptor signaling pathway
  • smoothened signaling pathway
  • myoblast development
  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
  • T cell differentiation
  • epithelial cell differentiation
  • cellular response to retinoic acid
  • positive regulation of epithelial cell differentiation
  • positive regulation of T cell differentiation
  • negative regulation of epithelial cell proliferation
  • lipid metabolic process
  • cellular response to cAMP
  • positive regulation of apoptotic process
  • cell fate commitment
  • hemopoietic stem cell proliferation
  • protein stabilization
  • regulation of proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

Where in the cell the gene product is active
  • extracellular space
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • frizzled binding
  • protein binding
  • receptor agonist activity
  • cytokine activity

Gene-Specific Assays for Results You Can Trust

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