Cd40lg Gene Summary [Rat]
Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of dendritic cell differentiation; and positive regulation of macromolecule biosynthetic process. Located in several cellular components, including cell body; cell surface; and extracellular space. Used to study Ehrlich tumor carcinoma; artery disease (multiple); autoimmune disease (multiple); thrombosis; and vitamin B12 deficiency. Biomarker of atherosclerosis; coronary artery disease; perinatal necrotizing enterocolitis; periodontal disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Orthologous to human CD40LG (CD40 ligand). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd40lg |
| Official Name | CD40 ligand [Source:RGD Symbol;Acc:708418] |
| Ensembl ID | ENSRNOG00000000871 |
| Bio databases IDs | |
| Aliases | CD40 ligand |
| Synonyms | CD154, CD40-L, CD40 ligand, gp39, hCD40L, HIGM1, IGM, IMD3, LOC84349, Ly-62, T-BAM, TNFSF5, Tnlg8b, TRAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd40lg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- CD40 receptor binding
- extracellular domain
- TNF homology domain
- TNF
- integrin binding
- intracellular domain
- TNF-like domain
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Cd40lg gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Atherosclerosis Signaling
- Autoimmune Thyroid Disease Signaling
- CD40 Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- IL-17 Signaling
- NF-κB Signaling
- Primary Immunodeficiency Signaling
- RAR Activation
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- T Helper Cell Differentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- experimental autoimmune encephalomyelitis
- immunodeficiency with hyper-IgM, type 1
- endometriosis
- primary biliary cirrhosis
- colitis
- dilated cardiomyopathy
- hyperplasia
- idiopathic hypereosinophilic syndrome
- rheumatoid arthritis
phenotypes
- Acute Coronary Syndrome
- Alzheimer's Disease
- Aortic Valve Calcification of
- Autoimmune Diseases
- B-Cell Chronic Lymphocytic Leukemia
- Behcet's disease
- Brain Injuries
- CD40 ligand deficiency
- Cholangiofibrosis
- Chronic Allograft Dysfunction
- Colonic Neoplasms
- Coronary Disease
- Diabetes Mellitus Experimental
- Diabetic Nephropathies
- Discoid Lupus Erythematosus
- Ehrlich tumor carcinoma
- Experimental Arthritis
- Experimental Autoimmune Myasthenia Gravis
- Experimental Autoimmune Neuritis
- Experimental Autoimmune Uveoretinitis
- Experimental Liver Neoplasms
- Fibrosis
- Graft vs Host Disease
- Graves Disease
- HELLP Syndrome
- Hashimoto Disease
- Hypercholesterolemia
- Kawasaki disease
- Lyme Neuroborreliosis
- Metabolic Syndrome
- Murine Acquired Immunodeficiency Syndrome
- Myocardial Ischemia
- Ovarian Neoplasms
- Overactive Urinary Bladder
- Primary Graft Dysfunction
- Reperfusion Injury
- Sepsis
- Shock
- Sjogren's Syndrome
- Subacute Combined Degeneration
- Transplant Rejection
- Vascular Calcification
- Viral Myocarditis
- Wounds Penetrating
- Acquired Immunodeficiency Syndrome
- allergic rhinitis
- amyotrophic lateral sclerosis
- anti-basement membrane glomerulonephritis
- Antiphospholipid Syndrome
- aplastic anemia
- asthma
- Atherosclerosis
- autoimmune thrombocytopenic purpura
- cardiovascular system disease
- carotid artery disease
- chronic lymphocytic leukemia
- combined T cell and B cell immunodeficiency
- congestive heart failure
- Coronary Artery Disease
- crescentic glomerulonephritis
- cutaneous lupus erythematosus
- Cystic Fibrosis
- dermatomyositis
- Diabetes Mellitus
- diabetic angiopathy
- Dysgammaglobulinemia
- end stage renal failure
- Eosinophilic Esophagitis
- Erythema Multiforme
- essential thrombocythemia
- factor VIII deficiency
- familial hyperlipidemia
- follicular lymphoma
- granulomatosis with polyangiitis
- hepatocellular carcinoma
- Herpes Simplex
- human immunodeficiency virus infectious disease
- kidney disease
- Lichen Planus
- Lupus Nephritis
- Malaria
- membranous glomerulonephritis
- migraine
- Multiple Myeloma
- Myocardial Infarction
- Narcolepsy
- Nephrosis
- obesity
- ovarian disease
- Pemphigus
- perinatal necrotizing enterocolitis
- periodontal disease
- Periodontitis
- Peritonitis
- Pre-Eclampsia
- precursor lymphoblastic lymphoma/leukemia
- pulmonary hypertension
- sickle cell anemia
- systemic lupus erythematosus
- Thrombocytopenia
- thrombosis
- tick-borne encephalitis
- transient cerebral ischemia
- type 1 diabetes mellitus
- type 2 diabetes mellitus
- urinary bladder cancer
- visceral leishmaniasis
- Vitamin B 12 Deficiency
- acute lymphoblastic leukemia
- Middle East respiratory syndrome
- end stage renal disease
- Experimental Diabetes Mellitus
role in cell
- proliferation
- expression in
- migration
- binding in
- phosphorylation in
- response
- growth
- apoptosis
- generation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- granules
- plasma membrane extracellular face
- cellular protrusions
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd40lg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- B cell differentiation
- T cell costimulation
- B cell proliferation
- positive regulation of T cell proliferation
- positive regulation of NF-kappaB transcription factor activity
- leukocyte cell-cell adhesion
- CD40 signaling pathway
- inflammatory response
- integrin-mediated signaling pathway
- positive regulation of interleukin-12 production
- negative regulation of apoptotic process
- regulation of immunoglobulin production
- positive regulation of endothelial cell apoptotic process
- positive regulation of interleukin-10 production
- platelet activation
- positive regulation of interleukin-4 production
- isotype switching
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- external side of plasma membrane
- Golgi apparatus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine kinase activator activity
- protein binding
- CD40 receptor binding
- tumor necrosis factor receptor binding
- integrin binding
- cytokine activity