Cry1 Gene Summary [Rat]
This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | Cry1 |
| Official Name | cryptochrome circadian regulator 1 [Source:RGD Symbol;Acc:735083] |
| Ensembl ID | ENSRNOG00000006622 |
| Bio databases IDs | |
| Aliases | cryptochrome circadian regulator 1 |
| Synonyms | cryptochrome circadian regulator 1, DSPD, DSPS, LOC100912243, PHLL1, PHOTOLYASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cry1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRK10674
- ligand-dependent nuclear receptor interactor
- protein kinase binding
- nucleic acid binding
- transcription factor binding
- histone deacetylase binding
- enzyme
- protein binding
- sequence-specific DNA binding
- cryptochrome, DASH family
- DNA binding
- kinase binding
- double-stranded DNA binding
- cryptochrome, plant family
- FAD binding domain of DNA photolyase
- DNA photolyase
- phosphatase binding
Pathways
Biological processes and signaling networks where the Cry1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- arthritis
- COVID-19
- diabetic nephropathy
- susceptibility to delayed sleep phase syndrome
- weight loss
- impaired glucose tolerance
role in cell
- expression in
- migration
- proliferation
- activation
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cry1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid storage
- signal transduction in response to DNA damage
- negative regulation of gluconeogenesis
- regulation of circadian rhythm
- response to light stimulus
- negative regulation of G-protein coupled receptor protein signaling pathway
- negative regulation of circadian rhythm
- positive regulation of gluconeogenesis
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- response to insulin stimulus
- negative regulation of transcription, DNA-dependent
- entrainment of circadian clock by photoperiod
- positive regulation of protein ubiquitination
- negative regulation of protein ubiquitination
- negative regulation of glucocorticoid secretion
- gluconeogenesis
- blue light signaling pathway
- circadian rhythm
- glucose homeostasis
- regulation of DNA damage checkpoint
- response to glucagon stimulus
- response to activity
- negative regulation of glucocorticoid receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- FAD binding
- protein kinase binding
- ligand-dependent nuclear receptor binding
- histone deacetylase binding
- blue light photoreceptor activity
- double-stranded DNA binding
- DNA binding
- protein binding
- DNA (6-4) photolyase activity
- deoxyribodipyrimidine photo-lyase activity
- E-box binding