Cyld Gene Summary [Rat]
Predicted to enable several functions, including deubiquitinase activity; proline-rich region binding activity; and zinc ion binding activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation protein catabolic process at postsynapse. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyld |
| Official Name | CYLD lysine 63 deubiquitinase [Source:RGD Symbol;Acc:1308346] |
| Ensembl ID | ENSRNOG00000014048 |
| Bio databases IDs | |
| Aliases | CYLD lysine 63 deubiquitinase |
| Synonyms | 2010013M14Rik, 2900009M21Rik, BRSS, C130039D01Rik, CDMT, CYLD1, CYLDI, CYLD lysine 63 deubiquitinase, EAC, FTDALS8, LOC100360670, LOC100362727, LOC100911739, LRRGT00003, MFT, MFT1, mKIAA0849, Rp1, Rp1h, SBS, TEM, USPL2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyld often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- traf2 binding domain
- transcription regulator
- protein kinase binding
- catalytic domain
- CAP-Gly domain
- protein binding
- Peptidase_C19
- NEMO-binding domain
- B-box-type zinc finger superfamily
- zinc ion binding
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- Ribosomal S3Ae family
- Phosphorylation region of CYLD, unstructured
- ubiquitin C-terminal hydrolase domain
- CAP_GLY
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colitis
- asthma
- epithelial cancer
- breast cancer
- nasopharyngeal carcinoma
- anal carcinoma
- anal cancer
- hyperplasia
- mixed sarcomatoid-epithelial nasopharyngeal carcinoma
role in cell
- expression in
- proliferation
- phosphorylation in
- migration
- apoptosis
- survival
- quantity
- cell death
- binding in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- spindle apparatus
- ciliary tip
- Cytoplasm
- intracellular space
- perinuclear region
- Plasma Membrane
- basal bodies
- centrosome
- microtubules
- midbody
- cytosol
- cytoplasmic face of plasma membrane
- nucleoplasm
- perinuclear space
- cytoplasmic microtubule
- central spindle
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cyld gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
- regulation of necroptosis
- necroptosis
- Wnt receptor signaling pathway
- protein deubiquitination
- negative regulation of type I interferon production
- negative regulation of interleukin-18-mediated signaling pathway
- regulation of intrinsic apoptotic signaling pathway
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of inflammatory response
- regulation of B cell differentiation
- negative regulation of JNK cascade
- regulation of mitotic cell cycle
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of T cell receptor signaling pathway
- innate immune response
- homeostasis of number of cells
- positive regulation of T cell differentiation
- regulation of tumor necrosis factor-mediated signaling pathway
- proteolysis
- regulation of inflammatory response
- positive regulation of extrinsic apoptotic signaling pathway
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- perinuclear region of cytoplasm
- cilium basal body
- spindle
- cytosol
- midbody
- cytoplasmic microtubule
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein kinase binding
- proline-rich region binding
- zinc ion binding
- protein binding