Gfra3 Gene Summary [Rat]
Predicted to enable axon guidance receptor activity and glial cell-derived neurotrophic factor receptor activity. Predicted to be involved in glial cell-derived neurotrophic factor receptor signaling pathway and nervous system development. Predicted to act upstream of or within axon guidance; neuron migration; and sympathetic nervous system development. Predicted to be located in cytosol. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Biomarker of sciatic neuropathy. Orthologous to human GFRA3 (GDNF family receptor alpha 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gfra3 |
| Official Name | GDNF family receptor alpha 3 [Source:RGD Symbol;Acc:620502] |
| Ensembl ID | ENSRNOG00000020309 |
| Bio databases IDs | |
| Aliases | GDNF family receptor alpha 3 |
| Synonyms | GDNF family receptor alpha 3, GDNF family receptor α 3, GDNFR3, GFRalpha3, glial cell line derived neurotrophic factor family receptor alpha 3, glial cell line derived neurotrophic factor family receptor α 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gfra3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glial cell line-derived neurotrophic factor receptor
- axon guidance receptor
- protein binding
- receptor binding
- transmembrane receptor
- coreceptor
- GDNF/GAS1 domain
Pathways
Biological processes and signaling networks where the Gfra3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cold allodynia
- ptosis
regulates
role in cell
- proliferation
- cell viability
- apoptosis
- cell death
- migration
- development
- colony formation
- guidance
- innervation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- cytosol
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gfra3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sympathetic nervous system development
- glial cell-derived neurotrophic factor receptor signaling pathway
- neuron migration
- signal transduction
- nervous system development
- axon guidance
- peripheral nervous system development
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- cytosol
- receptor complex
- extrinsic to membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- axon guidance receptor activity
- glial cell-derived neurotrophic factor receptor activity
- receptor binding