Kdr Gene Summary [Rat]
Enables growth factor binding activity and vascular endothelial growth factor receptor activity. Involved in several processes, including positive regulation of endothelial cell proliferation; positive regulation of intracellular signal transduction; and positive regulation of long-term neuronal synaptic plasticity. Located in neuronal cell body. Used to study adhesions of uterus; brain ischemia; cystitis; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); impotence; ovarian hyperstimulation syndrome; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); breast angiosarcoma; gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdr |
| Official Name | kinase insert domain receptor [Source:RGD Symbol;Acc:2965] |
| Ensembl ID | ENSRNOG00000046829 |
| Bio databases IDs | |
| Aliases | kinase insert domain receptor |
| Synonyms | 6130401C07, CD309, Flk, FLK1, Kinase Insert Domain, kinase insert domain protein receptor, kinase insert domain receptor, Krd-1, Ly73, orv, VEGFR, VEGFR-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kdr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- heat shock protein binding
- Protein kinase domain
- protein-tyrosine kinase
- identical protein binding
- VEGFR-2 Transmembrane domain
- cytoplasmic domain
- ligand-binding domain
- Immunoglobulin like
- vascular endothelial growth factor receptor
- intracellular domain
- immunoglobulin-like protein domain
- cadherin binding
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- growth factor binding
- transmembrane receptor
- coreceptor
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- ectodomain
- immunoglobulin domain
- Immunoglobulin I-set domain
- autophosphorylation site
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- integrin binding
- transmembrane domain
- tyrosine kinase domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Kdr gene in rat plays a role, providing insight into its function and relevance in health or disease.
- CREB Signaling in Neurons
- eNOS Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-15 Production
- IL-8 Signaling
- Inhibition of Angiogenesis by TSP1
- NF-κB Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- PTEN Signaling
- Role of Tissue Factor in Cancer
- Sperm Motility
- STAT3 Pathway
- VEGF Family Ligand-Receptor Interactions
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- leukemia
- neoplasia
- myelodysplastic syndrome
- acute myeloid leukemia
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- neuroendocrine lung tumor
role in cell
- expression in
- cell death
- phosphorylation in
- activation in
- apoptosis
- outgrowth
- accumulation
- growth
- synthesis in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- commissural axons
- Cytoplasm
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- plasma membrane extracellular face
- nodes of Ranvier
- growth cone
- early endosomes
- membrane rafts
- filopodia
- perikaryon
- axons
- sorting endosomes
- plasma
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kdr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- peptidyl-tyrosine phosphorylation
- embryonic hemopoiesis
- protein autophosphorylation
- endothelial cell differentiation
- cell migration involved in sprouting angiogenesis
- positive regulation of cell migration involved in sprouting angiogenesis
- positive regulation of angiogenesis
- lung alveolus development
- epithelial cell proliferation
- lymph vessel development
- negative regulation of endothelial cell apoptotic process
- positive regulation of macroautophagy
- vascular wound healing
- positive regulation of positive chemotaxis
- positive regulation of mesenchymal cell proliferation
- positive regulation of mitochondrial fission
- negative regulation of gene expression
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of focal adhesion assembly
- blood vessel endothelial cell differentiation
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of stem cell proliferation
- positive regulation of vasculogenesis
- mesenchymal cell proliferation
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
- regulation of cell shape
- regulation of MAPK cascade
- calcium ion homeostasis
- multicellular organismal development
- positive regulation of cell proliferation
- vasculogenesis
- surfactant homeostasis
- endocardium development
- negative regulation of neuron apoptotic process
- endothelium development
- angiogenesis
- patterning of blood vessels
- stem cell proliferation
- positive regulation of endothelial cell chemotaxis
- positive regulation of mitochondrial depolarization
- positive regulation of kinase activity
- cell migration
- positive regulation of endothelial cell migration
- epithelial cell maturation
- vascular endothelial growth factor signaling pathway
- peptidyl-tyrosine autophosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of MAPK cascade
- positive regulation of blood vessel endothelial cell migration
- ovarian follicle development
- positive regulation of BMP signaling pathway
- post-embryonic camera-type eye morphogenesis
- cell fate commitment
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- positive regulation of endothelial cell proliferation
- cellular response to vascular endothelial growth factor stimulus
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- Golgi apparatus
- endoplasmic reticulum
- receptor complex
- extracellular region
- plasma membrane
- nucleus
- early endosome
- endosome
- anchoring junction
- membrane raft
- cell junction
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- growth factor binding
- identical protein binding
- vascular endothelial growth factor-activated receptor activity
- integrin binding
- vascular endothelial growth factor binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- transmembrane receptor protein tyrosine kinase activity
- cadherin binding
- Hsp90 protein binding