Tnfaip6 Gene Summary [Rat]
Predicted to enable several functions, including carboxylesterase activity; fibronectin binding activity; and hyaluronic acid binding activity. Involved in positive regulation of cell migration. Located in extracellular space. Human ortholog(s) of this gene implicated in corneal neovascularization. Orthologous to human TNFAIP6 (TNF alpha induced protein 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfaip6 |
| Official Name | TNF alpha induced protein 6 [Source:RGD Symbol;Acc:621359] |
| Ensembl ID | ENSRNOG00000050792 |
| Bio databases IDs | |
| Aliases | TNF alpha induced protein 6 |
| Synonyms | TNF alpha induced protein 6, TNFIP6, TNF α induced protein 6, TSG-6, tumor necrosis factor alpha induced protein 6, tumor necrosis factor α induced protein 6, tumour necrosis factor alpha induced protein 6, tumour necrosis factor α induced protein 6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfaip6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carboxylic ester hydrolase
- CUB
- Link_Domain
- heparin binding domain
- calcium ion binding
- hyaluronan binding domain
- protein binding
- Extracellular link domain
- hyaluronic acid binding
- fibronectin binding
Pathways
Biological processes and signaling networks where the Tnfaip6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- rheumatoid arthritis
- eosinophilia
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- acute coronary syndrome
- experimentally-induced arthritis
- infiltrating ductal breast carcinoma
- invasive ductal breast cancer
role in cell
- expression in
- quantity
- activity
- production in
- phosphorylation in
- number
- differentiation
- activation
- expansion
- epithelial-mesenchymal transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ficolin-1-rich granule lumen
- organelle lumens
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfaip6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of inflammatory response
- negative regulation of neutrophil chemotaxis
- cell-cell signaling
- cell adhesion
- ovarian cumulus expansion
- negative regulation of osteoblast differentiation
- negative regulation of BMP signaling pathway
- inflammatory response
- negative regulation of osteoclast differentiation
- hyaluronan metabolic process
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- fibronectin binding
- hyaluronic acid binding