IBSP Gene Summary [Human]
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IBSP |
| Official Name | integrin binding sialoprotein [Source:HGNC Symbol;Acc:HGNC:5341] |
| Ensembl ID | ENSG00000029559 |
| Bio databases IDs | |
| Aliases | integrin binding sialoprotein, bone sialoprotein, bone sialoprotein II |
| Synonyms | BNSP, BONE SIALOPROTEIN, BSP, Bsp2, BSP-II, Integrin binding sialoprotein, SP-II |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IBSP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- poly(Glu) domain
- binding protein
- integrin binding
- protein binding
- Bone sialoprotein II (BSP-II)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- colon adenocarcinoma
- rectum cancer
- gastric adenocarcinoma
- breast cancer
- rectal adenocarcinoma
- colon cancer
- pancreatic adenocarcinoma
- breast carcinoma
- epithelial cancer
role in cell
- expression in
- proliferation
- invasion by
- differentiation
- migration
- colony formation
- number
- damage
- organization
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- biomineralization foci
- vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IBSP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- cellular response to growth factor stimulus
- osteoblast differentiation
- extracellular matrix organization
- cell adhesion
- positive regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding
- small molecule binding