CREB3L3 Gene Summary [Human]
This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | CREB3L3 |
| Official Name | cAMP responsive element binding protein 3 like 3 [Source:HGNC Symbol;Acc:HGNC:18855] |
| Ensembl ID | ENSG00000060566 |
| Bio databases IDs | |
| Aliases | cAMP responsive element binding protein 3 like 3, cAMP-responsive element-binding protein, hepatic-specific |
| Synonyms | BC010786, cAMP responsive element binding protein 3-like 3, CREB-H, D10Bur1e, HYST1481, HYTG2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CREB3L3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Basic region leucine zipper
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- protein homodimerization
- bZIP
- basic region leucin zipper
- protein heterodimerization
Pathways
Biological processes and signaling networks where the CREB3L3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- ATM Signaling
- Calcium Signaling
- Corticotropin Releasing Hormone Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Gαs Signaling
- Hypoxia Signaling in the Cardiovascular System
- IL-10 Signaling
- Iron homeostasis signaling pathway
- Melanocyte Development and Pigmentation Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Prostate Cancer Signaling
- Protein Kinase A Signaling
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Synaptic Long Term Potentiation
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- hepatic steatosis
- hypertriglyceridemia
- insulin resistance
- epithelial cancer
- weight loss
- obesity
- hyperlipidemia
- diabetes mellitus
role in cell
- expression in
- degradation in
- differentiation
- transactivation in
- production in
- upregulation in
- growth
- morphology
- transcription in
- osteogenic differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CREB3L3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of acute inflammatory response
- positive regulation of transcription from RNA polymerase II promoter
- response to unfolded protein
- response to endoplasmic reticulum stress
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- membrane
- cytosol
- endoplasmic reticulum
- Golgi membrane
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity