NFATC3 Gene Summary [Human]
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010]
Details
| Type | Retained Intron |
| Official Symbol | NFATC3 |
| Official Name | nuclear factor of activated T cells 3 [Source:HGNC Symbol;Acc:HGNC:7777] |
| Ensembl ID | ENSG00000072736 |
| Bio databases IDs | |
| Aliases | nuclear factor of activated T cells 3 |
| Synonyms | circNFATC3, circRNA-NFATC3, D8Ertd281e, n339260, NFAT3, NFAT4, NF-AT4c, Nfat4/x, NFATX, NFATX4, nuclear factor of activated T-cells 3, nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NFATC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SP repeat domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- IPT
- Rel homology dimerization domain
- CR1 domain
- nuclear localization sequence
- transcription activation domain
- transcription factor binding
- chromatin binding
- A2 domain
- calcineurin-binding domain
- protein binding
- sequence-specific DNA binding
- calcineurin-inhibitory domain
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- N-terminal sub-domain of the Rel homology domain (RHD)
- transcription factor activity
- A domain
Pathways
Biological processes and signaling networks where the NFATC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- April Mediated Signaling
- B Cell Activating Factor Signaling
- Calcium Signaling
- Cellular Effects of Sildenafil (Viagra)
- Chronic Myeloid Leukemia Signaling
- fMLP Signaling in Neutrophils
- G-Protein Coupled Receptor Signaling
- Glucocorticoid Receptor Signaling
- Gαq Signaling
- IL-12 Signaling and Production in Macrophages
- Natural Killer Cell Signaling
- Netrin Signaling
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
- T Cell Receptor Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Wnt/Ca+ pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- anemia
- Alzheimer disease
- tumorigenesis
- growth failure
- schizophrenia
- Hirschsprung disease
- hypoplasia
- colorectal cancer
- hypertension
role in cell
- expression in
- activity
- activation in
- hypertrophy
- proliferation
- migration
- apoptosis
- survival
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- apical cytoplasm
- apical membrane
- nucleoplasm
- Z line
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NFATC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcineurin-NFAT signaling cascade
- negative regulation of transcription from RNA polymerase II promoter
- inflammatory response
- positive regulation of nitric oxide biosynthetic process
- protein import into nucleus
- positive regulation of apoptotic process
- cytokine production
- positive regulation of cardiac muscle hypertrophy
- positive thymic T cell selection
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity