POLD3 Gene Summary [Human]
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the activity of DNA polymerase delta through interactions with other subunits and the processivity cofactor proliferating cell nuclear antigen (PCNA). Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
Details
| Type | Protein Coding |
| Official Symbol | POLD3 |
| Official Name | DNA polymerase delta 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:20932] |
| Ensembl ID | ENSG00000077514 |
| Bio databases IDs | |
| Aliases | DNA polymerase delta 3, accessory subunit, DNA polymerase delta subunit p66, Pol delta C subunit (p66), protein phosphatase 1, regulatory subunit 128 |
| Synonyms | 2410142G14Rik, DNA polymerase delta 3, accessory subunit, DNA polymerase δ 3, accessory subunit, IMD122, KIAA0039, P66, P68, polymerase (DNA-directed), delta 3, accessory subunit, polymerase (DNA-directed), δ 3, accessory subunit, PPP1R128 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLD3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PCNA binding domain
- DNA polymerase subunit Cdc27
- transcription regulator
- CR1 domain
- CR2 domain
- protein binding activity, bridging
- protein binding
Pathways
Biological processes and signaling networks where the POLD3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- COVID-19
- plexiform neurofibroma
- hepatocellular carcinoma
- liver cancer
- high-grade serous carcinoma
- gout
- colorectal cancer
- colorectal adenoma
role in cell
- length
- cell viability
- end-to-end fusion in
- end-to-end fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLD3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA strand elongation involved in DNA replication
- DNA-dependent DNA replication
- DNA biosynthetic process
- error-prone translesion synthesis
- nucleotide-excision repair, DNA gap filling
- mismatch repair
- DNA synthesis involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- delta DNA polymerase complex
- cytoplasm
- zeta DNA polymerase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed DNA polymerase activity
- protein binding
- protein binding, bridging