PHLPP1 Gene Summary [Human]
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling. [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | PHLPP1 |
| Official Name | PH domain and leucine rich repeat protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:20610] |
| Ensembl ID | ENSG00000081913 |
| Bio databases IDs | |
| Aliases | PH domain and leucine rich repeat protein phosphatase 1, protein phosphatase, Mg2+/Mn2+ dependent 3A |
| Synonyms | mKIAA0606, PH domain and leucine rich repeat protein phosphatase 1, PHLPP, PLEKHE1, PPM3A, SCOP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHLPP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- Protein phosphatase 2C
- protein serine/threonine phosphatase
- Leucine rich repeat
- enzyme
- protein binding
- Pleckstrin homology-like domain
- glutamine-rich domain
- Leucine Rich repeats (2 copies)
- Serine/threonine phosphatases, family 2C, catalytic domain
- leucine-rich repeat
- PH domain
- PP2Cc
Pathways
Biological processes and signaling networks where the PHLPP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- non-insulin-dependent diabetes mellitus
- colitis
- chronic lymphocytic leukemia
- weight loss
role in cell
- activation in
- expression in
- apoptosis
- survival
- invasion by
- proliferation
- phosphorylation in
- cell death
- growth
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- raft fractions
- cellular membrane
- Plasma Membrane
- lysosome
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHLPP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- entrainment of circadian clock
- regulation of T cell anergy
- signal transduction
- protein dephosphorylation
- apoptotic process
- regulation of apoptotic process
- regulation of p38MAPK cascade
- regulation of JNK cascade
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- metal ion binding
- myosin phosphatase activity