PPIF Gene Summary [Human]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is part of the mitochondrial permeability transition pore in the inner mitochondrial membrane. Activation of this pore is thought to be involved in the induction of apoptotic and necrotic cell death. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | PPIF |
| Official Name | peptidylprolyl isomerase F [Source:HGNC Symbol;Acc:HGNC:9259] |
| Ensembl ID | ENSG00000108179 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase F, cyclophilin D |
| Synonyms | CYCLOPHILIN3, cyclophilin F, CYP3, CyP-D, CyP-F, CyP-M, FLJ90798, hCyP3, peptidylprolyl isomerase F, peptidylprolyl isomerase F (cyclophilin F), PPIase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- cyclophilin
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclosporin A binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the PPIF gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- systemic lupus erythematosus
- pulmonary alveolar hemorrhage
- heart failure
- neurological disorder
- motor dysfunction
- uterine serous papillary cancer
- psoriasis
role in cell
- expression in
- activation in
- proliferation
- invasion by
- synthesis in
- migration
- apoptosis
- cell death
- organization
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial envelope
- cellular membrane
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of oxidative phosphorylation
- negative regulation of ATPase activity
- negative regulation of release of cytochrome c from mitochondria
- protein peptidyl-prolyl isomerization
- protein folding
- regulation of mitochondrial membrane permeability
- regulation of proton-transporting ATPase activity, rotational mechanism
- mitochondrial depolarization
- response to ischemia
- apoptotic mitochondrial changes
- cellular response to calcium ion
- necroptosis
- negative regulation of apoptotic process
- cellular response to arsenic-containing substance
- negative regulation of oxidative phosphorylation uncoupler activity
- cellular response to hydrogen peroxide
- negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- mitochondrial permeability transition pore complex
- cytoplasm
- mitochondrial matrix
- mitochondrion
- membrane
- mitochondrial proton-transporting ATP synthase complex
Molecular Function
What the gene product does at the molecular level
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- protein binding
- peptide binding