INO80B Gene Summary [Human]
This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | INO80B |
| Official Name | INO80 complex subunit B [Source:HGNC Symbol;Acc:HGNC:13324] |
| Ensembl ID | ENSG00000115274 |
| Bio databases IDs | |
| Aliases | INO80 complex subunit B, PAP-1 binding protein, IES2 homolog (S. cerevisiae) |
| Synonyms | 2510009I23Rik, hIes2, HMG1YL4, HMGA1L4, HMGIYL4, IES2, INO80 complex subunit B, NEWGENE 1562258, PAP-1BP, PAPA-1, RGD1562258, ZNHIT4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INO80B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger HIT (zf-HIT) domain
- PAPA-1-like conserved region
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INO80B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- DNA repair
- regulation of chromosome organization
- regulation of DNA strand elongation
- regulation of DNA repair
- DNA recombination
- regulation of embryonic development
- telomere maintenance
- regulation of DNA replication
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nuclear body
- Ino80 complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding