AKR1A1 Gene Summary [Human]
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
Details
| Type | Protein Coding |
| Official Symbol | AKR1A1 |
| Official Name | aldo-keto reductase family 1 member A1 [Source:HGNC Symbol;Acc:HGNC:380] |
| Ensembl ID | ENSG00000117448 |
| Bio databases IDs | |
| Aliases | aldo-keto reductase family 1 member A1, dihydrodiol dehydrogenase 3, aldehyde reductase |
| Synonyms | 2610201A18Rik, AKR1A4, ALDEHYDE REDUCTASE, aldo-keto reductase family 1 member A1, aldo-keto reductase family 1, member A1, ALDR1, ALR, ARM, DD3, HEL-S-6, hs.474584 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AKR1A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- L-glucuronate reductase
- glucuronolactone reductase
- Aldo-keto reductase (AKR) superfamily
- aldo-keto reductase
- CH-OH group:NAD or NADP oxidoreductase
- Aldo/keto reductase family
- enzyme
- protein binding
- aldehyde reductase
- alcohol dehydrogenase (NADP)
Pathways
Biological processes and signaling networks where the AKR1A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- COVID-19
- heart failure
- osteopenia
- rheumatoid arthritis
- androgenic alopecia
- ischemia/reperfusion-induced acute kidney injury
regulates
- TP53
- delta-12-prostaglandin J2
- lipid
- cholesterol
- daunorubicin
- aldehyde
- prostaglandin h2
- tryptophol
- indole-3-acetaldehyde
- erythrose 4-phosphate
role in cell
- apoptosis
- proliferation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- apical membrane
- synapse
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AKR1A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aldehyde catabolic process
- negative regulation of apoptotic process
- lipid metabolic process
- daunorubicin metabolic process
- glucuronate catabolic process to xylulose 5-phosphate
- doxorubicin metabolic process
- D-glucuronate catabolic process
- L-ascorbic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytosol
- synapse
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- L-glucuronate reductase activity
- retinol dehydrogenase activity
- protein binding
- alditol:NADP+ 1-oxidoreductase activity
- glucuronolactone reductase activity
- allyl-alcohol dehydrogenase activity
- aldo-keto reductase (NADP) activity
- S-nitrosoglutathione reductase activity
- glycerol dehydrogenase (NADP+) activity