TST Gene Summary [Human]
This is one of two neighboring genes encoding similar proteins that each contain two rhodanese domains. The encoded protein is localized to the mitochondria and catalyzes the conversion of thiosulfate and cyanide to thiocyanate and sulfite. In addition, the protein interacts with 5S ribosomal RNA and facilitates its import into the mitochondria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | TST |
| Official Name | thiosulfate sulfurtransferase [Source:HGNC Symbol;Acc:HGNC:12388] |
| Ensembl ID | ENSG00000128311 |
| Bio databases IDs | |
| Aliases | thiosulfate sulfurtransferase, rhodanese |
| Synonyms | RDS, RHODAN, Rhodanese, thiosulfate sulfurtransferase, thiosulfate sulfurtransferase, mitochondrial, thiosulfate sulphurtransferase, thiosulfate sulphurtransferase, mitochondrial |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TST often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sulfurtransferase
- 5S rRNA binding
- Rhodanese Homology Domain
- enzyme
- Rhodanese-like domain
- thiosulfate sulfurtransferase
- RHOD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- obesity
- non-small cell lung cancer
- Parkinson disease
- cervical cancer
- hepatitis B virus-related hepatocellular carcinoma
- hepatitis B surface antigen-negative hepatitis C virus negative hepatocellular carcinoma
regulates
- reactive oxygen species
- 5S
- cyanate
- sulfur amino acid
- sulfide
role in cell
- translation in
- differentiation
- perturbation
- disruption
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TST gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- sulfur amino acid catabolic process
- cyanate catabolic process
- rRNA import into mitochondrion
- rRNA transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- 5S rRNA binding
- thiosulfate sulfurtransferase activity
- 3-mercaptopyruvate sulfurtransferase activity