CAMSAP1 Gene Summary [Human]
Enables microtubule minus-end binding activity and spectrin binding activity. Involved in several processes, including neuron projection development; regulation of cell morphogenesis; and regulation of microtubule polymerization. Located in microtubule. Colocalizes with microtubule minus-end. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CAMSAP1 |
| Official Name | calmodulin regulated spectrin associated protein 1 [Source:HGNC Symbol;Acc:HGNC:19946] |
| Ensembl ID | ENSG00000130559 |
| Bio databases IDs | |
| Aliases | calmodulin regulated spectrin associated protein 1 |
| Synonyms | 9530003A05, 9530003A05Rik, C77823, calmodulin regulated spectrin-associated protein 1, CAMP1, CDCBM12, DKFZp434G2311, LOC157922, PRO2405, RGD1565022 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAMSAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Spectrin-binding region of Ca2+-Calmodulin
- calmodulin binding
- UDM1_RNF168_RNF169-like
- spectrin binding
- calponin homology (CH) domain superfamily
- Microtubule-binding calmodulin-regulated spectrin-associated
- protein binding
- Domain of unknown function (DUF4200)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- epithelial cancer
- complex cortical dysplasia with other brain malformations 12
- systemic lupus erythematosus
- nasopharyngeal carcinoma
- nasopharyngeal cancer
- Alzheimer disease
- seizures
- renal cell carcinoma
role in cell
- proliferation
- expression in
- growth
- differentiation
- migration
- aggregation
- formation
- invasion by
- morphogenesis
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAMSAP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoskeleton organization
- regulation of cell morphogenesis
- neuron projection development
- regulation of microtubule polymerization
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- microtubule organizing center
- cytoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- microtubule minus-end binding
- spectrin binding
- microtubule binding