ADGRB3 Gene Summary [Human]
This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ADGRB3 |
| Official Name | adhesion G protein-coupled receptor B3 [Source:HGNC Symbol;Acc:HGNC:945] |
| Ensembl ID | ENSG00000135298 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor B3 |
| Synonyms | A830096D10Rik, adhesion G protein-coupled receptor B3, BAI3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADGRB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Hormone receptor domain
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- 7 transmembrane receptor (Secretin family)
- extracellular domain
- GPCR-Autoproteolysis INducing (GAIN) domain
- GTPase activator
- protein binding
- zDHHC ankyrin repeat binding domain
- seven-transmembrane G protein-coupled receptor superfamily
- Adhesion GPCR B N-terminal region
- GPCR proteolysis site, GPS, motif
- Spondin-like TSP1 domain
Pathways
Biological processes and signaling networks where the ADGRB3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- COVID-19
- insomnia
- schizophrenia
- colorectal cancer
- cancer
- restless legs syndrome
- squamous cell lung cancer
- acute myeloid leukemia
- lung adenocarcinoma
regulated by
- TP53
- rebemadlin
- Influenza A virus (A/Japan/305/57(H2N2))
- methyl methanesulfonate
regulates
- insulin
role in cell
- quantity
- maturation
- remodeling
- fusion
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- synaptic cleft
- postsynaptic region
- cellular membrane
- synaptic membrane
- nerve ending
- synapse
- postsynaptic terminals
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADGRB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of synapse maturation
- negative regulation of angiogenesis
- G-protein coupled receptor signaling pathway
- myoblast fusion
- cell surface receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- neuron remodeling
- positive regulation of synapse assembly
- regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- synaptic cleft
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- GTPase activator activity