VAMP1 Gene Summary [Human]
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | VAMP1 |
| Official Name | vesicle associated membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:12642] |
| Ensembl ID | ENSG00000139190 |
| Bio databases IDs | |
| Aliases | vesicle associated membrane protein 1 |
| Synonyms | CMS25, lew, SAX1, SPAX1, SYB1, synaptobrevin 1, vesicle-associated membrane protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VAMP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- SNARE motif
- Synaptobrevin
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- traumatic brain injury
- adenoma formation
- stroke
- presynaptic congenital myasthenic syndrome type 25
- spastic paraplegia
- cerebral palsy
- autosomal dominant spastic ataxia type 1
- muscle spasticity
- chronic sialorrhea
role in cell
- expression in
- quantity
- size
- density
- exocytosis by
- priming
- exocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- azurophilic granule membrane
- glutaminergic synapse
- fibrillar organelles
- presynaptic regions
- cell surface
- cellular membrane
- Plasma Membrane
- endosomes
- Golgi Apparatus
- Mitochondria
- tertiary granule membrane
- specific granule membrane
- cytosol
- vesicle membrane
- synaptic vesicles
- neuromuscular junctions
- multivesicular bodies
- azurophil granules
- specific granules
- tertiary granules
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VAMP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle fusion
- SNARE complex assembly
Cellular Component
Where in the cell the gene product is active
- cytosol
- SNARE complex
- synaptic vesicle membrane
- mitochondrial outer membrane
- neuron projection
- azurophil granule membrane
- plasma membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- SNAP receptor activity