RRAGA Gene Summary [Human]
Enables several functions, including GTP binding activity; protein dimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Located in lysosome and nucleus. Colocalizes with GATOR1 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RRAGA |
| Official Name | Ras related GTP binding A [Source:HGNC Symbol;Acc:HGNC:16963] |
| Ensembl ID | ENSG00000155876 |
| Bio databases IDs | |
| Aliases | Ras related GTP binding A |
| Synonyms | 1300010C19Rik, FIP-1, RAGA, Ras-related GTP binding A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RRAGA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Gtr1/RagA G protein conserved region
- ubiquitin protein ligase binding
- Ras family
- protein binding activity, bridging
- phosphoprotein binding
- GTPase
- leucine zipper domain
- coiled-coil domain
- enzyme
- protein binding
- GTP binding
- nucleotide-binding domain
- protein homodimerization
- Ras of Complex, Roc, domain of DAPkinase
- protein heterodimerization
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypoglycemia
- focal cortical dysplasia of Taylor
role in cell
- expression in
- differentiation
- phagocytosis by
- proliferation
- activation in
- migration
- quantity
- cellular infiltration by
- autophagy by
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- lysosome
- cytosol
- lysosome membrane
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RRAGA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to amino acid starvation
- protein localization
- cellular response to starvation
- cellular response to amino acid stimulus
- tumor necrosis factor-mediated signaling pathway
- cellular response to nutrient levels
- negative regulation of autophagy
- glucose homeostasis
- apoptotic process
- protein localization in membrane
- positive regulation of TOR signaling cascade
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- lysosomal membrane
- lysosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein homodimerization activity
- ubiquitin protein ligase binding
- protein binding
- protein heterodimerization activity
- GTPase activity
- protein anchor
- phosphoprotein binding