HPGDS Gene Summary [Human]
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HPGDS |
| Official Name | hematopoietic prostaglandin D synthase [Source:HGNC Symbol;Acc:HGNC:17890] |
| Ensembl ID | ENSG00000163106 |
| Bio databases IDs | |
| Aliases | hematopoietic prostaglandin D synthase, glutathione S-transferase sigma |
| Synonyms | Class Sigma GST, Class σ GST, GSTS, GSTS1, GSTS1-1, Gst-ys, haematopoietic prostaglandin D synthase, hematopoietic prostaglandin D synthase, PGD2, PGDS, PROSTAGLANDIN D2 SYNTHASE, haematoPOIETIC, PROSTAGLANDIN D2 SYNTHASE, HEMATOPOIETIC, Ptgds2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HPGDS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- glutathione transferase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- calcium ion binding
- protein homodimerization
- enzyme
- protein binding
- magnesium ion binding
- prostaglandin-D synthase
Pathways
Biological processes and signaling networks where the HPGDS gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colitis-associated colon cancer
- muscular dystrophy
- COVID-19
- hyperplasia
- testicular germ cell tumor
- germ cell neoplasia
- head and neck neoplasia
- allergic rhinitis
- astrocytosis
role in cell
- expression in
- proliferation
- apoptosis
- damage
- infiltration by
- Th2 immune response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- cytosol
- cisternae
- nucleoplasm
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HPGDS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory behavior
- signal transduction
- glutathione metabolic process
- prostaglandin biosynthetic process
- negative regulation of male germ cell proliferation
- prostaglandin metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- prostaglandin-D synthase activity
- protein binding
- protein homodimerization activity
- calcium ion binding
- glutathione transferase activity