PPIB Gene Summary [Human]
The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
Details
| Type | Processed Transcript |
| Official Symbol | PPIB |
| Official Name | peptidylprolyl isomerase B [Source:HGNC Symbol;Acc:HGNC:9255] |
| Ensembl ID | ENSG00000166794 |
| Bio databases IDs | |
| Aliases | peptidylprolyl isomerase B, cyclophilin B, peptidyl-prolyl cis-trans isomerase B, rotamase B, S-cyclophilin |
| Synonyms | Cphn-2, CyP-20b, CYPB, CYP-S1, HEL-S-39, OI9, peptidylprolyl isomerase B, SCYLP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPIB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding domain
- peptidylprolyl isomerase
- Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
- cyclophilin
- nuclear localization sequence
- enzyme binding
- cyclosporin A binding
- collagen binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the PPIB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- metastasis
- colorectal cancer
- osteogenesis imperfecta type IX
- osteogenesis imperfecta
- colon adenocarcinoma
- colon epithelial cancer
- SERPINH1 R222S mutation positive severe osteogenesis imperfecta
- kyphosis
role in cell
- replication in
- growth
- proliferation
- migration
- survival
- invasion by
- abnormal morphology
- organization
- cell death
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- detergent-insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cell surface
- cell periphery
- perinuclear region
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum lumen
- nucleoplasm
- nucleoli
- smooth endoplasmatic reticulum
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPIB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- neutrophil chemotaxis
- protein peptidyl-prolyl isomerization
- protein folding
- protein stabilization
- positive regulation of multicellular organism growth
- bone development
Cellular Component
Where in the cell the gene product is active
- smooth endoplasmic reticulum
- endoplasmic reticulum
- nucleoplasm
- endoplasmic reticulum lumen
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- melanosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- macromolecular complex
- endoplasmic reticulum chaperone complex
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- cyclosporin A binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
- protein binding
- collagen binding
- unfolded protein binding