NRG4 Gene Summary [Human]
The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]
Details
| Type | Processed Transcript |
| Official Symbol | NRG4 |
| Official Name | neuregulin 4 [Source:HGNC Symbol;Acc:HGNC:29862] |
| Ensembl ID | ENSG00000169752 |
| Bio databases IDs | |
| Aliases | neuregulin 4 |
| Synonyms | HRG4, LOC686216, neuregulin 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NRG4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- receptor agonist activity
- protein binding
- EGF-like domain
- growth factor
Pathways
Biological processes and signaling networks where the NRG4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- insulin resistance
- ulcerative colitis
- gout
- Crohn disease
- experimental colitis
- hepatic steatosis
- chronic colitis
- androgenic alopecia
- prostate cancer
role in cell
- apoptosis
- expression in
- phosphorylation in
- growth
- quantity
- lipogenesis in
- proliferation
- activation in
- signaling in
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- apical compartment
- cellular membrane
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NRG4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ERBB4-ERBB4 signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- receptor agonist activity