SEMA4B Gene Summary [Human]
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SEMA4B |
| Official Name | semaphorin 4B [Source:HGNC Symbol;Acc:HGNC:10730] |
| Ensembl ID | ENSG00000185033 |
| Bio databases IDs | |
| Aliases | semaphorin 4B |
| Synonyms | mKIAA1745, SEMAC, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B, semaphorin 4B, SemC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SEMA4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- semaphorin domain
- Plexin repeat
- cytoplasmic domain
- immunoglobulin domain
- ectodomain
- protein binding
- Sema domain
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the SEMA4B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- breast cancer
- luminal B breast cancer
- acne
- lung adenocarcinoma formation
- seborrheic keratosis
- HER2 negative hormone receptor negative breast cancer
- proliferative diabetic retinopathy
- dermatological disorder
regulates
- AKT
- IgE
- phosphatidylinositol-3,4,5-triphosphate
- IgG1
role in cell
- proliferation
- phosphorylation in
- migration
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SEMA4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative chemotaxis
- neural crest cell migration
- axon guidance
- positive regulation of cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- chemorepellent activity
- semaphorin receptor binding