SRC Gene Summary [Human]
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | SRC |
| Official Name | SRC proto-oncogene, non-receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11283] |
| Ensembl ID | ENSG00000197122 |
| Bio databases IDs | |
| Aliases | SRC proto-oncogene, non-receptor tyrosine kinase |
| Synonyms | ASV, BS27, c-SRC, p60-Src, PP60, Pp60/c-Src, pp60c-src, Rous sarcoma oncogene, SRC1, SRC proto-oncogene, non-receptor tyrosine kinase, THC6, TVHUSC |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- membrane-association domain
- protein-tyrosine kinase
- unique protein domain
- phospholipase activator
- Src homology 2 (SH2) domain
- membrane targeting signal
- activation domain
- protein kinase binding
- SH2-domain binding
- Protein tyrosine and serine/threonine kinase
- catalytic domain
- protein kinase C binding
- protein binding
- heme binding
- basic helix loop helix/Per Arnt Sim domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- integrin binding
- UD domain
- tyrosine phosphorylation site
- myristoylation signal domain
- protein kinase
- LXXLL motif
- regulatory domain
- insulin receptor binding
- ATP-binding domain
- cell adhesion molecule binding
- receptor activator
- phosphoprotein binding
- ephrin receptor binding
- enzyme
- estrogen receptor binding
- Protein kinase domain
- Sh3 domain binding motif
- myristoylation sequence
- ligand-binding domain
- non-catalytic domain
- ion channel binding
- Tyrosine kinase, catalytic domain
- SH4 domain
- Protein kinase (unclassified specificity)
- negative regulatory domain
- enzyme binding
- non-membrane spanning protein tyrosine kinase
- protein domain specific binding
- autophosphorylation site
- receptor binding
- ionotropic glutamate receptor binding
- phosphotyrosine motif
- phosphorylation site
- Src Homology 3 domain superfamily
- ATPase binding
- binding protein
- Protein Kinases, catalytic domain
Pathways
Biological processes and signaling networks where the SRC gene in human plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Aryl Hydrocarbon Receptor Signaling
- Caveolar-mediated Endocytosis Signaling
- Chemokine Signaling
- Clathrin-mediated Endocytosis Signaling
- CXCR4 Signaling
- EGF Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Ephrin A Signaling
- ERK5 Signaling
- Estrogen-Dependent Breast Cancer Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Germ Cell-Sertoli Cell Junction Signaling
- Glucocorticoid Receptor Signaling
- Gαi Signaling
- Gαs Signaling
- HER-2 Signaling in Breast Cancer
- Macropinocytosis Signaling
- Neuregulin Signaling
- PDGF Signaling
- RANK Signaling in Osteoclasts
- Regulation of Cellular Mechanics by Calpain Protease
- Remodeling of Epithelial Adherens Junctions
- Sertoli Cell-Sertoli Cell Junction Signaling
- UVC-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastroesophageal junction adenocarcinoma
- metastatic esophageal adenocarcinoma
- esophageal adenocarcinoma
- mammary neoplasm
- non-insulin-dependent diabetes mellitus
- airway hyperresponsiveness
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
role in cell
- expression in
- binding
- proliferation
- transmembrane potential
- apoptosis
- hypertrophy
- cell viability
- production in
- activation in
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent-insoluble membrane fraction
- microsomal fraction
- plasma membrane fraction
- raft fractions
- membrane fraction
- apical ectoplasmic specialization
- glutaminergic synapse
- cell junction
- intracellular membrane-bounded organelle
- cytoskeleton
- organelle
- cell surface
- cell periphery
- perinuclear region
- cellular membrane
- focal adhesions
- podosomes
- Nucleus
- Plasma Membrane
- endosomes
- centrosome
- lysosome
- Endoplasmic Reticulum
- Mitochondria
- microtubules
- actin filaments
- midbody
- intercellular junctions
- cell-cell contacts
- cytoplasmic aggregates
- cytosol
- membrane ruffles
- caveolae
- synaptic membrane
- mitochondrial inner membrane
- nucleoplasm
- nuclear envelope
- growth cone
- neurites
- synaptosomes
- synapse
- late endosomes
- cytoplasmic vesicles
- zonula adherens
- lateral cell-cell contacts
- storage granules
- membrane rafts
- filopodia
- perikaryon
- axons
- dendrites
- synaptic vesicle fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell-cell adhesion
- positive regulation of Ras protein signal transduction
- regulation of bone resorption
- primary ovarian follicle growth
- cellular response to fluid shear stress
- cellular response to peptide hormone stimulus
- DNA biosynthetic process
- skeletal muscle cell proliferation
- intracellular signal transduction
- positive regulation of insulin receptor signaling pathway
- cellular response to platelet-derived growth factor stimulus
- platelet-derived growth factor receptor signaling pathway
- regulation of vascular permeability
- negative regulation of focal adhesion assembly
- nerve growth factor receptor signaling pathway
- vascular endothelial growth factor receptor signaling pathway
- positive regulation of bone resorption
- ephrin receptor signaling pathway
- response to interleukin-1
- progesterone receptor signaling pathway
- positive regulation of dephosphorylation
- regulation of heart rate by cardiac conduction
- positive regulation of podosome assembly
- positive regulation of protein kinase B signaling cascade
- regulation of early endosome to late endosome transport
- adherens junction organization
- response to xenobiotic stimulus
- Fc-gamma receptor signaling pathway involved in phagocytosis
- stimulatory C-type lectin receptor signaling pathway
- integrin-mediated signaling pathway
- cellular response to progesterone stimulus
- negative regulation of anoikis
- response to mineralocorticoid stimulus
- cellular response to fatty acid
- substrate adhesion-dependent cell spreading
- positive regulation of male germ cell proliferation
- regulation of epithelial cell migration
- negative regulation of protein complex assembly
- interleukin-6-mediated signaling pathway
- positive regulation of epithelial cell migration
- ERBB2 signaling pathway
- positive regulation of peptidyl-tyrosine phosphorylation
- macroautophagy
- regulation of cell projection assembly
- T cell costimulation
- positive regulation of lamellipodium morphogenesis
- negative regulation of inflammatory response to antigenic stimulus
- negative regulation of extrinsic apoptotic signaling pathway
- positive regulation of ovarian follicle development
- leukocyte migration
- positive regulation of integrin activation
- positive regulation of cytokine production
- peptidyl-tyrosine phosphorylation
- signal complex assembly
- epidermal growth factor receptor signaling pathway
- transforming growth factor beta receptor signaling pathway
- protein autophosphorylation
- stress fiber assembly
- branching involved in mammary gland duct morphogenesis
- learning or memory
- forebrain development
- transcytosis
- bone resorption
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- entry of bacterium into host cell
- cellular response to hypoxia
- response to electrical stimulus
- negative regulation of intrinsic apoptotic signaling pathway
- focal adhesion assembly
- positive regulation of protein localization to nucleus
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of gene expression
- positive regulation of glucose metabolic process
- positive regulation of small GTPase mediated signal transduction
- myoblast proliferation
- response to nutrient levels
- negative regulation of telomerase activity
- regulation of toll-like receptor 3 signaling pathway
- osteoclast development
- uterus development
- cell adhesion
- odontogenesis
- protein phosphorylation
- positive regulation of Notch signaling pathway
- response to mechanical stimulus
- cellular response to insulin stimulus
- positive regulation of protein transport
- positive regulation of protein processing
- cellular response to hydrogen peroxide
- negative regulation of mitochondrial depolarization
- positive regulation of smooth muscle cell migration
- platelet activation
- negative regulation of hippo signaling cascade
- regulation of caveolin-mediated endocytosis
- signal transduction
- spermatogenesis
- angiotensin-mediated signaling pathway
- intestinal epithelial cell development
- protein destabilization
- cellular response to lipopolysaccharide
- oogenesis
- negative regulation of apoptotic process
- innate immune response
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of apoptotic process
- cell differentiation
- positive regulation of platelet-derived growth factor receptor-beta signaling pathway
- regulation of intracellular estrogen receptor signaling pathway
- negative regulation of telomere maintenance via telomerase
- response to acidity
- positive regulation of protein serine/threonine kinase activity
Cellular Component
Where in the cell the gene product is active
- late endosome
- neuronal cell body
- synaptic membrane
- actin filament
- plasma membrane
- mitochondrial inner membrane
- lysosome
- podosome
- nucleoplasm
- caveola
- dendritic growth cone
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane raft
- mitochondrion
- cytosol
- cell junction
- ruffle membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- ephrin receptor binding
- protein kinase activity
- integrin binding
- SH2 domain binding
- insulin receptor binding
- receptor binding
- ion channel binding
- heme binding
- scaffold protein binding
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- cadherin binding
- connexin binding
- phospholipase binding
- phosphoprotein binding
- estrogen receptor binding
- phospholipase activator activity
- BMP receptor binding
- enzyme binding
- ATPase binding