GK Gene Summary [Human]
The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | GK |
| Official Name | glycerol kinase [Source:HGNC Symbol;Acc:HGNC:4289] |
| Ensembl ID | ENSG00000198814 |
| Bio databases IDs | |
| Aliases | glycerol kinase |
| Synonyms | ASTP, D930012N15RIK, GK1, GKD, Glycerokinase, glycerol kinase, GYK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- FGGY family of carbohydrate kinases, C-terminal domain
- glycerol kinase
- FGGY family of carbohydrate kinases, N-terminal domain
- enzyme
- protein binding
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the GK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- hereditary disorder
- growth failure
- deficiency of glycerol kinase
- hepatic steatosis
- hypoglycemia
- progressive familial intrahepatic cholestasis type 1
regulated by
- LH
- LY294002
- DGKE
- oleic acid
- dexamethasone
- isobutylmethylxanthine
- adenosine triphosphate
- streptozocin
- insulin
- CL 316243
role in cell
- expression in
- phosphorylation in
- activation in
- accumulation in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- microsome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- glycerol-3-phosphate biosynthetic process
- triglyceride biosynthetic process
- glycerol catabolic process
- triglyceride metabolic process
- phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- glycerol kinase activity