Pou2f2 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and spermidine transmembrane transporter activity. Involved in cellular response to virus; positive regulation of macromolecule biosynthetic process; and spermidine transport. Acts upstream of or within cell maturation; mature B cell differentiation; and positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; nervous system; sensory organ; and thymus. Orthologous to human POU2F2 (POU class 2 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou2f2 |
| Official Name | POU domain, class 2, transcription factor 2 [Source:MGI Symbol;Acc:MGI:101897] |
| Ensembl ID | ENSMUSG00000008496 |
| Bio databases IDs | |
| Aliases | POU domain, class 2, transcription factor 2 |
| Synonyms | 2-Oct, OCT2, Oct2a, Oct2b, OTF2, POU class 2 homeobox 2, POU domain, class 2, transcription factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pou2f2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- transcription activation domain
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- spermidine transporter
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Pou2f2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- childhood nodular lymphocyte-predominant Hodgkin lymphoma
- nodular lymphocyte predominance Hodgkin disease
- childhood Hodgkins disease
- mediastinal gray zone lymphoma
- mediastinal cancer
- histiocytosis-lymphadenopathy plus syndrome
- cyanosis
role in cell
- cell viability
- expression in
- proliferation
- activation in
- binding in
- development
- differentiation
- number
- self-renewal
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- apical membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pou2f2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- humoral immune response
- positive regulation of interleukin-6 production
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity