Esr2 Gene Summary [Mouse]
Enables DNA binding activity. Acts upstream of or within several processes, including hormone-mediated signaling pathway; nervous system development; and reproductive structure development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; ganglia; genitourinary system; limb segment; and mammary gland primordium. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); bone disease (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Esr2 |
| Official Name | estrogen receptor 2 (beta) [Source:MGI Symbol;Acc:MGI:109392] |
| Ensembl ID | ENSMUSG00000021055 |
| Bio databases IDs | |
| Aliases | estrogen receptor 2 (beta) |
| Synonyms | beta ESTROGEN receptor, Erb, ER[b], ERB2, ER-beta, ER-β, ESRB, ESR-BETA, ESR-β, ESTRB, estrogen receptor 2, estrogen receptor 2 (beta), estrogen receptor 2 (β), estrogen receptor beta, Estrogen receptor β, NR3A2, ODG8, β ESTROGEN receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Esr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc finger DNA binding domain
- LXXLL motif
- transcription regulator
- steroid hormone receptor
- A/B region
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- transcription activation domain
- AF-2 transcription activation domain
- chromatin binding
- F domain
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- P-box
- peroxisome proliferator activated receptor binding
- AF-1 domain
- ligand-binding domain
- estrogen receptor
- ligand-dependent nuclear receptor
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- hormone binding
- estrogen receptor C domain
- estrogen receptor A/B domain
- DNA binding domain
- amphipathic helix
- nucleic acid binding
- enzyme binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- steroid binding
- binding protein
- Estrogen receptor beta
- estrogen receptor alpha E/F domain
- double-stranded DNA binding
- hinge domain
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
- C-terminal extension
Pathways
Biological processes and signaling networks where the Esr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- astrocytosis
- neoplasia
- epithelial cancer
- Alzheimer disease
- pain
- obesity
- psoriasis
- major depression
- polycystic ovary syndrome
- hypertension
role in cell
- expression in
- activation in
- function
- phosphorylation in
- production in
- proliferation
- number
- quantity
- activation
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- plasma membrane fraction
- nuclear fraction
- soluble fraction
- nuclear membrane fraction
- mitochondrial fraction
- intracellular membrane-bounded organelle
- perinuclear mitochondria
- peripheral mitochondria
- Cytoplasm
- cell surface
- perinuclear region
- Plasma Membrane
- vesicles
- Mitochondria
- cytosol
- microsome
- caveolae
- inner nuclear membrane
- nucleoplasm
- dendritic spines
- nerve ending
- chromatin
- perikaryon
- axons
- dendrites
- axon terminals
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Esr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to estradiol stimulus
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- signal transduction
- cell-cell signaling
- regulation of transcription, DNA-dependent
- positive regulation of sequence-specific DNA binding transcription factor activity
- cellular response to estrogen stimulus
- intracellular estrogen receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- estrogen response element binding
- estrogen receptor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- receptor antagonist activity
- steroid binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- steroid hormone receptor activity
- enzyme binding