Adcy5 Gene Summary [Mouse]

Enables adenylate cyclase activity; adenylate cyclase binding activity; and scaffold protein binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; locomotory behavior; and neuromuscular process controlling balance. Located in cilium and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Parkinson's disease. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Adcy5
Official Name
adenylate cyclase 5 [Source:MGI Symbol;Acc:MGI:99673]
Ensembl ID
ENSMUSG00000022840
Bio databases IDs NCBI: 224129 Ensembl: ENSMUSG00000022840
Aliases adenylate cyclase 5
Synonyms AC5, Ac type V, adenylate cyclase 5, Adenylyl Cyclase5, DSKOD, FDFM
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adcy5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • C1A domain
  • Adenylyl cyclase N-terminal extracellular and transmembrane region
  • enzyme
  • protein binding
  • Adenylate cyclase, conserved domain
  • C2 domain (from adenylate cyclase)
  • cytoplasmic domain
  • adenylate cyclase binding
  • adenylate cyclase
  • C2II subdomain (from adenylate cyclase)
  • calcium/calmodulin-responsive adenylate cyclase
  • Class III nucleotidyl cyclases
  • Adenylyl- / guanylyl cyclase, catalytic domain
  • C1 domain (from adenylate cyclase)
  • C2I subdomain (from adenylate cyclase)

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • liver cancer
  • epithelial cancer
  • non-insulin-dependent diabetes mellitus
  • COVID-19
  • chronic obstructive pulmonary disease
  • familial dyskinesia with facial myokymia
  • hereditary disorder
  • hepatocellular carcinoma
  • Huntington disease
  • diabetic retinopathy
regulated by
  • IFNG
  • PKA catalytic subunit
  • G protein alpha i
  • succinic acid
  • RGS2
  • DRD2
  • Core
  • 2'/3'-O-N-methylanthraniloyl-ITP-gamma-S
  • SERPINA6
  • vidarabine
regulates
  • BCL2
  • Ca2+
  • histone H3
  • AKT
  • D-glucose
  • MAPK1
  • ERK
  • cyclic AMP
  • GNAS
  • renin
role in cell
  • apoptosis
  • phosphorylation in
  • production in
  • long term synaptic depression
  • response by
  • elevation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cilia
  • cellular membrane
  • endosomes
  • primary cilia
  • sarcolemma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Adcy5 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
  • cAMP biosynthetic process
  • regulation of insulin secretion involved in cellular response to glucose stimulus
  • adenosine receptor signaling pathway
  • adenylate cyclase-activating dopamine receptor signaling pathway
  • locomotory behavior
  • adenylate cyclase-inhibiting dopamine receptor signaling pathway
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • neuromuscular process controlling balance
  • intracellular signal transduction
  • elevation of cytosolic calcium ion concentration

Cellular Component

Where in the cell the gene product is active
  • membrane
  • cilium
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • ATP binding
  • scaffold protein binding
  • metal ion binding
  • adenylate cyclase binding
  • adenylate cyclase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.