Anapc2 Gene Summary [Mouse]
This gene encodes a component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle by ubiquitinating its specific substrates, such as mitotic cyclins and anaphase inhibitor, for subsequent degradation by the proteasome. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | Anapc2 |
| Official Name | anaphase promoting complex subunit 2 [Source:MGI Symbol;Acc:MGI:2139135] |
| Ensembl ID | ENSMUSG00000026965 |
| Bio databases IDs | |
| Aliases | anaphase promoting complex subunit 2 |
| Synonyms | 9230107K09Rik, Anaphase promoting complex subunit 2, APC2, Emi4, IMI4, mKIAA1406 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Anapc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase promoting complex (APC) subunit 2
- protein binding
- Cullin
Pathways
Biological processes and signaling networks where the Anapc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriatic arthritis
- male pattern hair loss
- acute liver failure
- infection by HIV-1
- productive infection by HIV-1
role in cell
- maturation
- morphogenesis
- extension
- replication in
- cell cycle progression in
- integration in
- integration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Anapc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse maturation
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- nervous system development
- positive regulation of axon extension
- regulation of mitotic cell cycle
- cell division
- regulation of meiotic cell cycle
- negative regulation of gene expression
- positive regulation of synaptic plasticity
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- cell differentiation
- mitotic metaphase/anaphase transition
- positive regulation of dendrite morphogenesis
Cellular Component
Where in the cell the gene product is active
- anaphase-promoting complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding