Adra1d Gene Summary [Mouse]
Enables alpha1-adrenergic receptor activity. Involved in neuron-glial cell signaling and regulation of blood pressure. Acts upstream of or within negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure and norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure. Predicted to be active in plasma membrane. Is expressed in brain; diencephalon; and forebrain. Orthologous to human ADRA1D (adrenoceptor alpha 1D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adra1d |
| Official Name | adrenergic receptor, alpha 1d [Source:MGI Symbol;Acc:MGI:106673] |
| Ensembl ID | ENSMUSG00000027335 |
| Bio databases IDs | |
| Aliases | adrenergic receptor, alpha 1d |
| Synonyms | [a]1d, ADRA1, ADRA1A, ADRA1R, Adrd1, adrenergic receptor, alpha 1d, adrenergic receptor, α 1d, adrenoceptor alpha 1D, adrenoceptor α 1D, ALPHA1, Alpha1d adrenoceptor, alpha1D-AR, DAR, dJ779E11.2, Gpcr8, Spr8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adra1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- alpha1-adrenergic receptor
Pathways
Biological processes and signaling networks where the Adra1d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetes mellitus
- disorder of coronary artery
- cardiovascular death
- cardiovascular disorder
- acute coronary syndrome
- insulin resistance
- metabolic syndrome X
- stroke
- myocardial infarction
role in cell
- activation in
- apoptosis
- production in
- proliferation
- generation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- cellular membrane
- granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adra1d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- adenylate cyclase-activating adrenergic receptor signaling pathway
- positive regulation of cell proliferation
- positive regulation of vasoconstriction
- cell-cell signaling
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- phospholipase C-activating G-protein coupled receptor signaling pathway
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- alpha1-adrenergic receptor activity