Atp9a Gene Summary [Mouse]
Predicted to enable ATPase-coupled intramembrane lipid transporter activity and protease binding activity. Involved in neuron projection morphogenesis. Located in early endosome and late endosome. Is expressed in several structures, including alimentary system; central nervous system; hemolymphoid system gland; peripheral nervous system; and retina. Used to study specific developmental disorder. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth and behavioral abnormalities. Orthologous to human ATP9A (ATPase phospholipid transporting 9A (putative)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp9a |
| Official Name | ATPase, class II, type 9A [Source:MGI Symbol;Acc:MGI:1330826] |
| Ensembl ID | ENSMUSG00000027546 |
| Bio databases IDs | |
| Aliases | ATPase, class II, type 9A |
| Synonyms | ATPase, class II, type 9A, Atpase iia, ATPase phospholipid transporting 9A (putative), ATPIIA, IIa, KIAA0611, NEDGBA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp9a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- Mg2+-ATPase
- Phospholipid-translocating ATPase N-terminal
- protein binding
- P-type ATPase of unknown pump specificity (type V)
- E1-E2 ATPase
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Phospholipid-translocating P-type ATPase C-terminal
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- cancer
- neurodevelopmental disorder with poor growth and behavioral abnormalities
- advanced cancer
- bipolar disorder
role in cell
- growth
- phosphorylation in
- migration
- inhibition
- invasion by
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear body
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- trans Golgi network
- endosomal membrane
- insulin secretory granules
- recycling endosomes
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp9a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid translocation
- retrograde vesicle-mediated transport, Golgi to ER
- neuron projection morphogenesis
- endocytosis
- regulation of endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- trans-Golgi network
- early endosome
- perinuclear region of cytoplasm
- endosome
- late endosome
- recycling endosome
- recycling endosome membrane
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- protein binding
- protease binding