Tnfrsf1b Gene Summary [Mouse]
Enables tumor necrosis factor receptor activity. Involved in several processes, including negative regulation of extracellular matrix constituent secretion; regulation of nervous system development; and semi-lunar valve development. Acts upstream of or within several processes, including RNA destabilization; apoptotic signaling pathway; and negative regulation of inflammatory response. Located in membrane raft. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system; liver; and trunk. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to human TNFRSF1B (TNF receptor superfamily member 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf1b |
| Official Name | tumor necrosis factor receptor superfamily, member 1b [Source:MGI Symbol;Acc:MGI:1314883] |
| Ensembl ID | ENSMUSG00000028599 |
| Bio databases IDs | |
| Aliases | tumor necrosis factor receptor superfamily, member 1b |
| Synonyms | CD120b, p70TNFR, p75, p75TNFR, p80, P80 TNF receptor, TBPII, TNF-alphaR2, TNF alpha RII, TNFBR, Tnfr-1, TNFR1B, TNF-R2, TNF-R75, TNFR80, TNF receptor superfamily member 1B, TNF-R-II, TNF-RII/TNFRSF1B, TNFR P75, TNF α RII, tumor necrosis factor receptor superfamily, member 1b, tumour necrosis factor receptor superfamily, member 1b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tnfrsf1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- traf2 binding domain
- extracellular domain
- stem region
- cytokine binding
- ectodomain
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- pre-ligand assembly domain
- TRAF binding domain
- cytoplasmic domain
- tumor necrosis factor receptor
- ligand-binding domain
- transmembrane domain
- tyrosine kinase domain
- intracellular domain
- cytosolic tail domain
- transmembrane receptor
- cysteine rich domain
Pathways
Biological processes and signaling networks where the Tnfrsf1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Apoptosis Signaling
- Autophagy
- Ceramide Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Death Receptor Signaling
- Dendritic Cell Maturation
- Docosahexaenoic Acid (DHA) Signaling
- Hepatic Cholestasis
- IL-6 Signaling
- Induction of Apoptosis by HIV1
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Myc Mediated Apoptosis Signaling
- NF-κB Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- Role of Tissue Factor in Cancer
- T Helper Cell Differentiation
- Tight Junction Signaling
- TNFR2 Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- seizures
- neoplasia
- obesity
- epithelial neoplasia
- benign neoplasia
- skin cancer
- insulin resistance
- hypophagia
- rheumatoid arthritis
role in cell
- phosphorylation in
- cell death
- suppression
- accumulation
- apoptosis
- expression in
- proliferation
- expansion
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- axon component
- Cytoplasm
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- perinuclear region
- cellular membrane
- cytoplasmic aggregates
- specific granule membrane
- lateral cell surfaces
- neurites
- membrane rafts
- perikaryon
- axons
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tnfrsf1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of T cell proliferation
- extrinsic apoptotic signaling pathway
- DNA damage response, signal transduction resulting in induction of apoptosis
- aortic valve development
- pulmonary valve development
- negative regulation of extracellular matrix constituent secretion
- positive regulation of oligodendrocyte differentiation
- inflammatory response
- tumor necrosis factor-mediated signaling pathway
- immune response
- cellular response to lipopolysaccharide
- positive regulation of membrane protein ectodomain proteolysis
- regulation of T cell cytokine production
- negative regulation of cardiac muscle hypertrophy
- cellular response to growth factor stimulus
- regulation of myelination
- regulation of cytokine production involved in immune response
- RNA destabilization
- positive regulation of myelination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- varicosity
- membrane raft
- membrane
- neuronal cell body
- extracellular region
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- tumor necrosis factor-activated receptor activity
- tumor necrosis factor binding