Ctbp2 Gene Summary [Mouse]
Enables several functions, including nuclear retinoic acid receptor binding activity; transcription coregulator activity; and transcription coregulator binding activity. A structural constituent of presynaptic active zone. Involved in negative regulation of DNA-templated transcription; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within cellular response to leukemia inhibitory factor; positive regulation of retinoic acid receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus and ribbon synapse. Part of transcription repressor complex. Is active in several cellular components, including photoreceptor ribbon synapse; presynaptic active zone cytoplasmic component; and presynaptic cytosol. Is expressed in several structures, including extraembryonic component; ganglia; sensory organ; telencephalon; and tooth. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Ctbp2 |
| Official Name | C-terminal binding protein 2 [Source:MGI Symbol;Acc:MGI:1201686] |
| Ensembl ID | ENSMUSG00000030970 |
| Bio databases IDs | |
| Aliases | C-terminal binding protein 2 |
| Synonyms | C-terminal binding protein 2, D7Ertd45e, Gtrgeo6, Ribeye |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- transcription regulator
- transcription co-activator
- protein kinase binding
- transcription co-repressor
- retinoic acid receptor binding
- nuclear localization sequence
- RIBEYE B domain
- transcription factor binding
- chromatin binding
- D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- protein binding
- identical protein binding
- Mdm2 protein binding domain
- ARF domain
- NAD binding domain
- binding protein
- dehydrogenase homology domain
- PDZ binding motif
- structural molecule
- D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Pathways
Biological processes and signaling networks where the Ctbp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- metastasis
- epithelial cancer
- bleeding
- COVID-19
- metabolic syndrome X
- refractive error
- sensorineural hearing loss
- hearing loss
- prostate cancer
role in cell
- expression in
- apoptosis
- proliferation
- migration
- growth
- invasion by
- differentiation
- binding
- migratory capacity
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- polycomb group domain
- glutaminergic synapse
- cytosol
- nucleoplasm
- nerve ending
- synapse
- photoreceptor outer segments
- filopodial tip
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- white fat cell differentiation
- positive regulation of retinoic acid receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- negative regulation of cell proliferation
- viral genome replication
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- synapse
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- transcription cofactor binding
- protein kinase binding
- protein binding
- transcription coactivator activity
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
- NAD binding
- transcription corepressor activity