Agt Gene Summary [Mouse]
Enables receptor ligand activity; type 1 angiotensin receptor binding activity; and type 2 angiotensin receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; aldosterone secretion; and angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; positive regulation of metabolic process; and regulation of systemic arterial blood pressure by renin-angiotensin. Located in extracellular space. Is active in extracellular region. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Fabry disease; IgA vasculitis; artery disease (multiple); heart conduction disease (multiple); and hydronephrosis. Orthologous to human AGT (angiotensinogen). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Agt |
| Official Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [Source:MGI Symbol;Acc:MGI:87963] |
| Ensembl ID | ENSMUSG00000031980 |
| Bio databases IDs | |
| Aliases | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| Synonyms | AGTN, ANG, Angiotensinogen, ANHU, ANRT, Aogen, hFLT1, LOC105373166, PAT, SERPINA8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Agt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- superoxide-generating NADPH oxidase activator
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- G-protein-coupled receptor binding
- signal peptide
- sodium channel regulator
- hormone
- receptor agonist activity
- protein binding
- growth factor
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the Agt gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- cancer
- kidney injury
- neoplasia
- infection
- essential hypertension
- multiple sclerosis
- COVID-19
- abdominal aortic aneurysm
- proteinuria
role in cell
- expression in
- adipogenesis
- binding in
- cell viability
- growth
- calcium response in
- fragmentation
- differentiation
- glycolysis in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- Cytoplasm
- cell surface
- Nucleus
- Plasma Membrane
- Mitochondria
- secretory granules
- brush border
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Agt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAP kinase activity
- low-density lipoprotein particle remodeling
- positive regulation of protein tyrosine kinase activity
- positive regulation of epidermal growth factor receptor signaling pathway
- G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
- vasoconstriction
- positive regulation of NF-kappaB transcription factor activity
- renal system process
- positive regulation of epithelial to mesenchymal transition
- regulation of blood volume by renin-angiotensin
- positive regulation of protein metabolic process
- negative regulation of nerve growth factor receptor signaling pathway
- renin-angiotensin regulation of aldosterone production
- regulation of renal output by angiotensin
- positive regulation of transcription, DNA-dependent
- kidney development
- positive regulation of fibroblast proliferation
- regulation of renal sodium excretion
- positive regulation of activation of Janus kinase activity
- positive regulation of cardiac muscle hypertrophy
- positive regulation of endothelial cell migration
- positive regulation of reactive oxygen species metabolic process
- regulation of vasoconstriction
- response to muscle activity involved in regulation of muscle adaptation
- G-protein coupled receptor signaling pathway
- positive regulation of inflammatory response
- angiotensin-mediated signaling pathway
- cell-cell signaling
- regulation of apoptotic process
- phospholipase C-activating G-protein coupled receptor signaling pathway
- regulation of blood pressure
- regulation of blood vessel size by renin-angiotensin
- nitric oxide-cGMP-mediated signaling pathway
- regulation of cell proliferation
- positive regulation of branching involved in ureteric bud morphogenesis
- blood vessel remodeling
- regulation of cell growth
- positive regulation of extrinsic apoptotic signaling pathway
- positive regulation of macrophage derived foam cell differentiation
- positive regulation of cytokine production
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- type 2 angiotensin receptor binding
- growth factor activity
- serine-type endopeptidase inhibitor activity
- type 1 angiotensin receptor binding
- protein binding
- hormone activity