Topbp1

Predicted to enable several functions, including identical protein binding activity; phosphorylation-dependent protein binding activity; and protein serine/threonine kinase activator activity. Predicted to be involved in several processes, including broken chromosome clustering; double-strand break repair; and mitotic G2/M transition checkpoint. Predicted to act upstream of or within reciprocal meiotic recombination. Located in condensed nuclear chromosome and male germ cell nucleus. Is expressed in cerebral cortex ventricular layer; embryo; and metanephros. Orthologous to human TOPBP1 (DNA topoisomerase II binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Topbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Topbp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Topbp1 gene, providing context for its role in the cell.