Prkar2a Gene Summary [Mouse]
Predicted to enable several functions, including beta-2 adrenergic receptor binding activity; cAMP binding activity; and enzyme binding activity. Involved in modulation of chemical synaptic transmission. Located in cytoplasm. Part of cAMP-dependent protein kinase complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and leg. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkar2a |
| Official Name | protein kinase, cAMP dependent regulatory, type II alpha [Source:MGI Symbol;Acc:MGI:108025] |
| Ensembl ID | ENSMUSG00000032601 |
| Bio databases IDs | |
| Aliases | protein kinase, cAMP dependent regulatory, type II alpha |
| Synonyms | 1110061A24Rik, cAK RII α, PKAR2alpha, PKAR2α, Pka rII α, Pkarsa, PKR2, PRKAR2, protein kinase, cAMP dependent regulatory, type II alpha, protein kinase, cAMP dependent regulatory, type II α, protein kinase cAMP-dependent type II regulatory subunit alpha, protein kinase cAMP-dependent type II regulatory subunit α, RII alpha, RII(alpha), RII α, RII(α) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkar2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cAMP binding domain
- ubiquitin protein ligase binding
- protein kinase
- protein kinase A binding
- protein kinase binding
- G-protein-coupled receptor binding
- protein domain specific binding
- DD_R_PKA_DPY30-like
- protein binding
- cAMP-dependent protein kinase regulator
- identical protein binding
- Cyclic nucleotide-monophosphate binding domain
- phosphorylation site
- kinase
- Cyclic nucleotide-binding domain
- binding protein
- B domain
- cAMP-dependent protein kinase inhibitor activity
- 3',5'-cAMP binding
- CAP_ED
Pathways
Biological processes and signaling networks where the Prkar2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Gαs Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Relaxin Signaling
- Renin-Angiotensin Signaling
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric adenocarcinoma
- Alzheimer disease
- kidney stones
- gout
- gastric epithelial cancer
role in cell
- expression in
- phosphorylation in
- binding in
- contact growth inhibition
- invasion by
- epithelial-mesenchymal transition
- signal transduction in
- M2 polarization
- decondensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosomal fraction
- cytocentrum fractions
- caveolae fraction
- soluble fraction
- membrane fraction
- glutaminergic synapse
- Golgi-centrosome region
- cell surface
- perinuclear region
- outer membranes
- cellular membrane
- Nucleus
- Plasma Membrane
- centrosome
- Golgi Apparatus
- Mitochondria
- axonemes
- cytosol
- caveolae
- lateral plasma membrane
- chromosome
- sperm tail
- germinal vesicles
- neurites
- synapse
- sarcolemma
- transverse tubules
- membrane rafts
- chromatin
- perikaryon
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkar2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cAMP-dependent protein kinase activity
- regulation of protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- centrosome
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- cAMP-dependent protein kinase complex
- axoneme
- plasma membrane
- AMP-activated protein kinase complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- ubiquitin protein ligase binding
- protein binding
- protein kinase A catalytic subunit binding
- cAMP binding
- cAMP-dependent protein kinase regulator activity
- cAMP-dependent protein kinase inhibitor activity