Inpp4b Gene Summary [Mouse]
Enables lipid binding activity; phosphatidylinositol bisphosphate phosphatase activity; and phosphatidylinositol trisphosphate phosphatase activity. Acts upstream of or within several processes, including negative regulation of osteoclast differentiation; regulation of bone remodeling; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; ear; genitourinary system; heart; and musculoskeletal system. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Inpp4b |
| Official Name | inositol polyphosphate-4-phosphatase, type II [Source:MGI Symbol;Acc:MGI:2158925] |
| Ensembl ID | ENSMUSG00000037940 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate-4-phosphatase, type II |
| Synonyms | E130107I17RIK, inositol polyphosphate-4-phosphatase, type II, inositol polyphosphate-4-phosphatase type II B, IPP4P2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inpp4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inositol-1,3,4-trisphosphate 4-phosphatase
- lipid binding
- inositol bisphosphate phosphatase
- phosphatase
- protein binding
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- hypertension
- osteoporosis
- neoplasia
- acute myeloid leukemia
- tumorigenesis
- metastasis
- malaria
- organismal death
- alcoholism
role in cell
- expression in
- proliferation
- quantity
- phosphorylation in
- activation in
- growth
- migration
- number
- formation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Inpp4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- signal transduction
- phosphatidylinositol-3-phosphate biosynthetic process
- phosphatidylinositol biosynthetic process
- phosphatidylinositol dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
- protein binding
- inositol-1,3,4-trisphosphate 4-phosphatase activity
- inositol-3,4-bisphosphate 4-phosphatase activity