Vtcn1 Gene Summary [Mouse]
Enables signaling receptor binding activity. Acts upstream of or within positive regulation of interleukin-2 production; regulation of T cell activation; and response to protozoan. Located in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system gland; liver; lung; male reproductive gland or organ; and pancreas. Orthologous to human VTCN1 (V-set domain containing T cell activation inhibitor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vtcn1 |
| Official Name | V-set domain containing T cell activation inhibitor 1 [Source:MGI Symbol;Acc:MGI:3039619] |
| Ensembl ID | ENSMUSG00000051076 |
| Bio databases IDs | |
| Aliases | V-set domain containing T cell activation inhibitor 1 |
| Synonyms | B7-H4, B7h.5, B7S1, B7X, PRO1291, RGD1311204, VCTN1, V-set domain containing T cell activation inhibitor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vtcn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobin constant region like domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- immunoglobulin variable region-like domain
- protein binding
- receptor binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- infection
- neoplasia
- lung cancer
- juvenile rheumatoid arthritis
- metastasis
- experimental autoimmune encephalomyelitis
- organismal death
- collagen-induced arthritis
- ovarian cancer
role in cell
- expression in
- activation
- proliferation
- apoptosis
- inhibition
- G1/S phase transition
- cell cycle progression
- cell viability
- quantity
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vtcn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- negative regulation of T cell proliferation
- adaptive immune response
- positive regulation of T cell proliferation
- regulation of cytokine production
- negative regulation of T cell activation
- T cell receptor signaling pathway
- response to protozoan
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- receptor binding