Lifr Gene Summary [Mouse]
Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and leukemia inhibitory factor receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Acts upstream of or within positive regulation of cell population proliferation. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study CAKUT. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lifr |
| Official Name | LIF receptor alpha [Source:MGI Symbol;Acc:MGI:96788] |
| Ensembl ID | ENSMUSG00000054263 |
| Bio databases IDs | |
| Aliases | LIF receptor alpha |
| Synonyms | A230075M04RIK, AW061234, CD118, Gp190, leukaemia inhibitory factor receptor, LIF, LIFR ALPHA, LIFR beta, LIF receptor, LIF receptor alpha, LIF receptor subunit alpha, LIF receptor subunit α, LIF receptor α, LIFR α, LIFR β, LOC105374734, SJS2, STWS, SWS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lifr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine binding
- Fibronectin type 3 domain
- cytoplasmic domain
- oncostatin-M receptor
- immunoglobulin-like protein domain
- intracellular domain
- ciliary neurotrophic factor receptor
- leukemia inhibitory factor receptor
- transmembrane receptor
- growth factor binding
- SHP-2 binding domain
- fibronectin-like domain
- proline-rich box
- extracellular domain
- immunoglobulin domain
- ectodomain
- protein binding
- Leukemia inhibitory factor receptor N-terminal domain
- cytokine binding module
- Leukemia inhibitory factor receptor D2 domain
- cytokine receptor homology domain
- ciliary neurotrophic factor receptor binding
- FN3
- transmembrane domain
- YXXQ motif
Pathways
Biological processes and signaling networks where the Lifr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- breast cancer
- colorectal cancer
- epithelial cancer
- liver cancer
- neoplasia
- serous ovarian adenocarcinoma
- Stuve-Wiedemann syndrome type 1
- serous ovarian cancer
- lung adenocarcinoma
role in cell
- proliferation
- invasion by
- migration
- cell viability
- expression in
- activation in
- chemotaxis
- activation
- phosphorylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- membrane rafts
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lifr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- oncostatin-M-mediated signaling pathway
- leukemia inhibitory factor signaling pathway
- cytokine-mediated signaling pathway
- ciliary neurotrophic factor-mediated signaling pathway
- positive regulation of cell proliferation
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- external side of plasma membrane
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ciliary neurotrophic factor receptor activity
- growth factor binding
- protein binding
- oncostatin-M receptor activity
- leukemia inhibitory factor receptor activity
- cytokine binding
- ciliary neurotrophic factor receptor binding
- cytokine receptor activity