Scn3a Gene Summary [Mouse]
Predicted to enable calmodulin binding activity; sodium ion binding activity; and voltage-gated sodium channel activity. Involved in behavioral response to pain. Located in membrane and sarcoplasm. Is expressed in gut; heart; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 62 and familial focal epilepsy with variable foci 4. Orthologous to human SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn3a |
| Official Name | sodium channel, voltage-gated, type III, alpha [Source:MGI Symbol;Acc:MGI:98249] |
| Ensembl ID | ENSMUSG00000057182 |
| Bio databases IDs | |
| Aliases | sodium channel, voltage-gated, type III, alpha |
| Synonyms | DEE62, EIEE62, FFEVF4, Gm1000, LOC100360249, LOC100360303, NAC3, Nav1.3, SCIII, Scn2a, sodium channel, voltage-gated, type III, alpha, sodium channel, voltage-gated, type III, α, sodium voltage-gated channel alpha subunit 3, sodium voltage-gated channel α subunit 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scn3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium ion transport-associated
- Voltage-dependent L-type calcium channel, IQ-associated
- voltage-gated sodium channel
- Cytoplasmic domain of voltage-gated Na+ ion channel
- sodium channel
- Ion transport protein
- calmodulin binding
- metal ion binding
- protein binding
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Scn3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- familial focal epilepsy with variable foci 4
- bipolar disorder
- partial seizure with secondary generalization
- migraines
- neurodevelopmental disorder
- early infantile epileptic encephalopathy type 62
- epilepsy
- multiple system atrophy
- spinocerebellar ataxia type 2
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- cell surface
- cellular membrane
- sarcoplasm
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scn3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- sodium ion transport
- behavioral response to pain
- sodium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- sarcoplasm
- voltage-gated sodium channel complex
Molecular Function
What the gene product does at the molecular level
- voltage-gated sodium channel activity