Rad51b Gene Summary [Mouse]
Predicted to enable ATP-dependent activity, acting on DNA; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within blastocyst growth; positive regulation of cell population proliferation; and somite development. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in replication fork. Is expressed in cerebral cortex; cranial ganglion; dorsal root ganglion; neural retina; and ventral grey horn. Orthologous to human RAD51B (RAD51 paralog B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rad51b |
| Official Name | RAD51 paralog B [Source:MGI Symbol;Acc:MGI:1099436] |
| Ensembl ID | ENSMUSG00000059060 |
| Bio databases IDs | |
| Aliases | RAD51 paralog B |
| Synonyms | LOC100912751, mREC2, R51H2, RAD51L1, RAD51 paralog B, REC2, RGD1560681 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rad51b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA repair and recombination protein RadA
- meiotic recombinase Dmc1
- DNA secondary structure binding
- Rad51
- enzyme
- protein binding
- DNA dependent ATPase
- DNA repair protein RAD51
- DNA binding
- AAA domain
- DNA repair and recombination protein RadB
- single-stranded DNA binding
- double-stranded DNA binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Rad51b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- cancer
- epithelial cancer
- neoplasia
- asthma
- prostatic carcinoma
- prostate cancer
- breast carcinoma
- rheumatoid arthritis
- allergy
role in cell
- proliferation
- homologous recombination in
- cohesion
- cohesion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rad51b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- blastocyst growth
- reciprocal meiotic recombination
- somite development
- positive regulation of cell proliferation
- double-strand break repair via homologous recombination
- DNA recombination
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- replication fork
- Rad51B-Rad51C-Rad51D-XRCC2 complex
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- DNA-dependent ATPase activity
- protein binding
- double-stranded DNA binding
- four-way junction DNA binding
- single-stranded DNA binding