Slc27a4

Enables oleoyl-CoA ligase activity and very long-chain fatty acid-CoA ligase activity. Involved in glucose import in response to insulin stimulus; long-chain fatty acid import into cell; and negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity. Acts upstream of or within several processes, including fatty acid metabolic process; fatty acid transport; and skin development. Located in brush border membrane; endoplasmic reticulum; and microvillus. Is expressed in several structures, including alimentary system; eye; nervous system; skin; and urinary system. Used to study restrictive dermopathy. Orthologous to human SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc27a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Slc27a4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc27a4 gene, providing context for its role in the cell.