Trerf1 Gene Summary [Mouse]
Predicted to enable nuclear progesterone receptor binding activity; transcription coactivator binding activity; and transcription coregulator activity. Predicted to be involved in cellular response to steroid hormone stimulus and regulation of DNA-templated transcription. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; genitourinary system; gut; and hemolymphoid system. Orthologous to human TRERF1 (transcriptional regulating factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Trerf1 |
| Official Name | transcriptional regulating factor 1 [Source:MGI Symbol;Acc:MGI:2442086] |
| Ensembl ID | ENSMUSG00000064043 |
| Bio databases IDs | |
| Aliases | transcriptional regulating factor 1 |
| Synonyms | 9430096I18Rik, AI429294, B830015H24, BCAR2, dJ139D8.5, HSA277276, RAPA, transcriptional regulating factor 1, TREP132 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trerf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- SANT
- transcription regulator
- ligand-dependent nuclear receptor interactor
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- transcription co-activator
- ELM2 domain
- Myb-like DNA-binding domain
- transcription factor binding
- protein binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- peripheral T-cell lymphoma
- schizophrenia
- postural instability
- mammary neoplasm
- colitis
- chronic obstructive pulmonary disease
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- chickenpox
role in cell
- proliferation
- expression in
- quantity
- replication in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trerf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to progesterone stimulus
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- progesterone receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- cytosol
- histone deacetylase complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- metal ion binding
- transcription corepressor activity
- progesterone receptor binding
- ligand-dependent nuclear receptor transcription coactivator activity
- transcription coactivator binding