Dgkd Gene Summary [Mouse]
Enables ATP-dependent diacylglycerol kinase activity. Involved in diacylglycerol catabolic process; negative regulation of phospholipase C/protein kinase C signal transduction; and positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in clathrin-coated pit; cytoplasmic vesicle; and cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; immune system; musculature; reproductive system; and sensory organ. Used to study Lennox-Gastaut syndrome. Orthologous to human DGKD (diacylglycerol kinase delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dgkd |
| Official Name | diacylglycerol kinase, delta [Source:MGI Symbol;Acc:MGI:2138334] |
| Ensembl ID | ENSMUSG00000070738 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase, delta |
| Synonyms | D330025K09, dgkd-2, DGK-delta, DGK delta 1, DGK delta2, DGK-δ, DGK δ 1, diacylglycerol kinase delta, diacylglycerol kinase, delta, diacylglycerol kinase δ, diacylglycerol kinase, δ, RGD1563309 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dgkd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- diacylglycerol kinase
- SAM (Sterile alpha motif )
- SAM domain
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- Sterile alpha motif
- kinase binding
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- SAM domain (Sterile alpha motif)
- protein homodimerization
- PH domain
- Diacylglycerol kinase catalytic domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Dgkd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- kidney stones
- acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
- urolithiasis
- hyperglycemia
- open-angle glaucoma
- dyspnea
- eyelids open at birth
- obesity
- gastric adenocarcinoma
role in cell
- quantity
- expression in
- activation
- apoptosis
- proliferation
- phosphorylation in
- migration
- ubiquitination in
- degradation in
- incorporation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- Nucleus
- Plasma Membrane
- cytosol
- nuclear rim
- cytoplasmic vesicles
- clathrin-coated pits
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dgkd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein kinase C signaling cascade
- signal transduction
- positive regulation of clathrin-mediated endocytosis
- protein transport
- positive regulation of epidermal growth factor receptor signaling pathway
- endocytosis
- protein kinase C-activating G-protein coupled receptor signaling pathway
- lipid phosphorylation
- phosphatidic acid biosynthetic process
- diacylglycerol metabolic process
- platelet activation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- coated pit
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- metal ion binding
- diacylglycerol binding
- diacylglycerol kinase activity
- kinase binding