Tap1 Gene Summary [Rat]
Enables several functions, including ATP hydrolysis activity; TAP binding activity; and adenyl ribonucleotide binding activity. Contributes to peptide antigen binding activity. Involved in peptide transport and protection from natural killer cell mediated cytotoxicity. Part of TAP complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune disease (multiple); bronchial disease (multiple); diffuse scleroderma; and lung disease (multiple). Orthologous to human TAP1 (transporter 1, ATP binding cassette subfamily B member). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tap1 |
| Official Name | transporter 1, ATP binding cassette subfamily B member [Source:RGD Symbol;Acc:3817] |
| Ensembl ID | ENSRNOG00000000457 |
| Bio databases IDs | |
| Aliases | transporter 1, ATP binding cassette subfamily B member |
| Synonyms | ABC17, ABCB2, APT1, Cim, D6S114E, Ham-1, MHC1D1, MTP1, PSF-1, RING4, TAP, TAP1*0102N, TAP1N, Tap2, TRANSPORTER 1 ATP-binding CASSETTE SUBFAMILY B, transporter 1, ATP-binding cassette, sub-family B (MDR/TAP), transporter 1, ATP binding cassette subfamily B member, TRANSPORTER 1 (MDR/TAP), Y3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FeS assembly ATPase SufC
- TAP2 binding
- MHC class I protein binding
- ATP-binding domain
- TAP1 binding
- ADP binding
- ATP binding
- Conjugate Transporter-2 (CT2) Family protein
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- nucleotide-binding domain
- thiol reductant ABC exporter, CydC subunit
- MHC protein binding
- energy-coupling factor transporter ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- nucleotide binding
- lipid A export permease/ATP-binding protein MsbA
- walker type A motif
- protein binding
- major histocompatibility peptide transporter
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- thiol reductant ABC exporter, CydD subunit
- binding protein
- tapasin binding
- transmembrane domain
- protein homodimerization
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- peptide antigen binding
- transporter
Pathways
Biological processes and signaling networks where the Tap1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insulin-dependent diabetes mellitus
- lung squamous cell carcinoma
- gastric adenocarcinoma
- gastrointestinal neoplasia
- dermatomyositis
- prostate cancer
- epithelial cancer
- cholangiocarcinoma
- cholangiocarcinoma cancer
role in cell
- expression in
- quantity
- activation in
- number
- growth
- phosphorylation in
- abnormal morphology
- function
- cytolysis by
- antigen presentation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- centrosome
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
- nuclear envelope
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- protein transport
- adaptive immune response
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- defense response
- cytosol to ER transport
- peptide transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- MHC class I peptide loading complex
- TAP complex
- centriolar satellite
- membrane
- phagocytic vesicle membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- peptide antigen-transporting ATPase activity
- protein homodimerization activity
- peptide antigen binding
- MHC class Ib protein binding
- MHC class I protein binding
- ADP binding
- TAP1 binding
- TAP2 binding
- ATP binding
- protein binding
- metal ion binding