Coro1c Gene Summary [Rat]
Predicted to enable actin filament binding activity and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of cell-substrate adhesion; regulation of cell migration; and regulation of plasma membrane bounded cell projection organization. Predicted to act upstream of or within corpus callosum development and ventricular system development. Predicted to be located in several cellular components, including endosome membrane; lamellipodium; and lateral plasma membrane. Predicted to be part of flotillin complex. Orthologous to human CORO1C (coronin 1C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coro1c |
| Official Name | coronin 1C [Source:RGD Symbol;Acc:1564490] |
| Ensembl ID | ENSRNOG00000000697 |
| Bio databases IDs | |
| Aliases | coronin 1C |
| Synonyms | COR1C, coronin 1C, coronin, actin binding protein 1C, CRN2, HCRNN4, RGD1564490 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Coro1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- actin filament binding
- Type of WD40 repeat
- WD40 repeats
- enzyme binding
- WD domain, G-beta repeat
- WD40
- protein binding
- Domain of unknown function (DUF1899)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- thrombocytosis
- Marfan syndrome
- coronary artery disease
- endometrial cancer
- infection by Influenza A virus subtype H1N1
role in cell
- apoptosis
- expression in
- proliferation
- invasion by
- migration
- phagocytosis by
- organization
- tubulation
- sprouting by
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- soluble fraction
- endoplasmic reticulum fraction
- mitochondrial fraction
- detergent resistant lipid raft fraction
- cytoskeleton
- cilia
- perinuclear region
- cortical rim
- actin cytoskeleton
- Plasma Membrane
- vesicles
- cell-cell contacts
- plasma membrane projections
- lateral plasma membrane
- endosomal membrane
- cell membrane leading edge
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Coro1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- signal transduction
- positive regulation of lamellipodium morphogenesis
- negative regulation of substrate adhesion-dependent cell spreading
- regulation of substrate adhesion-dependent cell spreading
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- actin filament organization
- regulation of ruffle assembly
- corpus callosum development
- ventricular system development
- establishment of protein localization
- negative regulation of focal adhesion assembly
- regulation of focal adhesion assembly
- neural crest cell migration
- regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- phagocytosis
- endosomal transport
- negative regulation of epithelial cell migration
- regulation of epithelial cell migration
- regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- synapse
- focal adhesion
- sarcolemma
- cell cortex
- actin cytoskeleton
- vesicle
- ruffle membrane
- endosome membrane
- sarcomere
- lamellipodium
- flotillin complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- small GTPase binding