Abcd4 Gene Summary [Rat]
Predicted to enable ABC-type vitamin B12 transporter activity and identical protein binding activity. Predicted to be involved in cobalamin metabolic process and cobalamin transport. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum membrane and peroxisome. Predicted to be active in lysosomal membrane. Orthologous to human ABCD4 (ATP binding cassette subfamily D member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcd4 |
| Official Name | ATP binding cassette subfamily D member 4 [Source:RGD Symbol;Acc:1307273] |
| Ensembl ID | ENSRNOG00000011964 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily D member 4 |
| Synonyms | ABC41, ATP binding cassette subfamily D member 4, ATP-binding cassette, sub-family D member 4, EST352188, MAHCJ, P69r, P70R, P79R, PMP69, PXMP1L |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ABC transporter transmembrane region 2
- vitamin B12-transporting ATPase
- Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
- protein binding
- ABC transporter
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
- lysosome membrane
- peroxisome membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- transmembrane transport
- peroxisome organization
- very long-chain fatty acid catabolic process
- cobalamin metabolic process
- cobalamin transport
- peroxisomal long-chain fatty acid import
Cellular Component
Where in the cell the gene product is active
- peroxisomal membrane
- endoplasmic reticulum membrane
- peroxisome
- membrane
- lysosomal membrane
- ATP-binding cassette (ABC) transporter complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- identical protein binding
- ATPase activity, coupled to transmembrane movement of substances
- cobalamin-transporting ATPase activity
- protein binding
- long-chain fatty acid transporter activity