Nrp2 Gene Summary [Mouse]
Enables semaphorin receptor activity. Involved in several processes, including nervous system development; outflow tract septum morphogenesis; and ventral trunk neural crest cell migration. Acts upstream of or within several processes, including axon guidance; cellular response to leukemia inhibitory factor; and trunk neural crest cell migration. Located in axon. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Nrp2 |
| Official Name | neuropilin 2 [Source:MGI Symbol;Acc:MGI:1100492] |
| Ensembl ID | ENSMUSG00000025969 |
| Bio databases IDs | |
| Aliases | neuropilin 2 |
| Synonyms | 1110048P06RIK, Neuropilin-2, NP2, NPN2, PRO2714, VEGF165R2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- C-terminal domain of neuropilin glycoprotein
- signaling receptor activity
- Coagulation factor 5/8 C-terminal domain, discoidin domain
- extracellular B domain
- ectodomain
- extracellular A domain
- protein binding
- identical protein binding
- kinase
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- CUB
- transmembrane domain
- coagulation factor domain
- F5/8 type C domain
- vascular endothelial growth factor receptor
- semaphorin receptor
- transmembrane receptor
- MAM domain, meprin/A5/mu
- growth factor binding
- FA58C
Pathways
Biological processes and signaling networks where the Nrp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epilepsy
- seizures
- neoplasia
- bleeding
- COVID-19
- diabetic nephropathy
- autism
- hereditary disorder
- non-insulin-dependent diabetes mellitus
- mental retardation
phenotypes
- abnormal anterior commissure morphology
- abnormal anterior commissure pars posterior morphology
- abnormal axon guidance
- abnormal dendrite morphology
- abnormal dendritic spine morphology
- abnormal habenula morphology
- abnormal hippocampal mossy fiber morphology
- abnormal hippocampus neuron morphology
- abnormal innervation
- abnormal lymphangiogenesis
- abnormal lymphatic system physiology
- abnormal lymphatic vessel endothelial cell morphology
- abnormal lymphatic vessel morphology
- abnormal nervous system development
- abnormal nervous system physiology
- abnormal neuronal migration
- abnormal oculomotor nerve morphology
- abnormal olfactory neuron innervation pattern
- abnormal sensory neuron innervation pattern
- abnormal spinal cord dorsal column morphology
- abnormal synaptic plasticity
- abnormal trigeminal nerve morphology
- abnormal vomeronasal sensory neuron morphology
- abnormal vomeronasal sensory neuron physiology
- absent trochlear nerve
- decreased body size
- decreased cell proliferation
- environmentally induced seizures
- hydrocephaly
- increased sensitivity to induced morbidity/mortality
- increased susceptibility to pharmacologically induced seizures
- lymphatic vessel hyperplasia
- myoclonus
- perinatal lethality incomplete penetrance
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- prenatal lethality incomplete penetrance
- reduced fertility
- seizures
role in cell
- cell death
- expression in
- production in
- proliferation
- activation in
- damage in
- phosphorylation in
- migration
- quantity
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptosomal membrane fractions
- glutaminergic synapse
- cell surface
- cellular membrane
- postsynaptic membrane
- growth cone
- synaptosomes
- synapse
- cytoplasmic vesicles
- membrane processes
- filopodial tip
- perikaryon
- axons
- dendrites
- axon terminals
- apical processes
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus
- negative chemotaxis
- trigeminal nerve structural organization
- vestibulocochlear nerve structural organization
- vascular endothelial growth factor signaling pathway
- axon guidance
- cell adhesion
- facial nerve structural organization
- nerve development
- axon extension involved in axon guidance
- branchiomotor neuron axon guidance
- outflow tract septum morphogenesis
- angiogenesis
- positive regulation of endothelial cell proliferation
- positive regulation of endothelial cell migration
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- postsynaptic membrane
- membrane
- extracellular region
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- growth factor binding
- protein binding
- metal ion binding
- signaling receptor activity
- semaphorin receptor activity
- vascular endothelial growth factor-activated receptor activity
- heparin binding
- cytokine binding