Il2ra Gene Summary [Mouse]
Enables interleukin-2 binding activity and interleukin-2 receptor activity. Acts upstream of or within several processes, including Notch signaling pathway; activation-induced cell death of T cells; and regulation of T cell proliferation. Located in external side of plasma membrane. Is expressed in bone marrow and yolk sac. Used to study Sjogren's syndrome and inflammatory bowel disease. Human ortholog(s) of this gene implicated in immunodeficiency 41; lymphopenia; multiple sclerosis; type 1 diabetes mellitus; and type 1 diabetes mellitus 10. Orthologous to human IL2RA (interleukin 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il2ra |
| Official Name | interleukin 2 receptor, alpha chain [Source:MGI Symbol;Acc:MGI:96549] |
| Ensembl ID | ENSMUSG00000026770 |
| Bio databases IDs | |
| Aliases | interleukin 2 receptor, alpha chain |
| Synonyms | CD25, IDDM10, IL2R, IL2RAC, Il 2 receptor α subunit, Il2r α, IMD41, interleukin 2 receptor, alpha chain, interleukin 2 receptor subunit alpha, interleukin 2 receptor subunit α, interleukin 2 receptor α, Interleukin 2 receptor α chain, interleukin 2 receptor, α chain, Ly-43, p55, TAC, TAC ANTIGEN, TCGFR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il2ra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- extracellular domain
- Shc binding site
- cytoplasmic domain
- ectodomain
- transmembrane domain
- protein binding
- cytosolic tail domain
- transmembrane receptor
- SUSHI repeat
- interleukin-2 receptor
- interleukin-2 binding
Pathways
Biological processes and signaling networks where the Il2ra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- ulcerative colitis
- dermatological disorder
- epithelial cancer
- renal clear cell adenocarcinoma
- high risk neuroblastoma
- leukemia
- vitiligo vulgaris
- rheumatoid arthritis
phenotypes
- abnormal colon morphology
- abnormal duodenum morphology
- abnormal freezing behavior
- abnormal spleen morphology
- abnormal vertebrae morphology
- decreased body length
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating HDL cholesterol level
- decreased circulating alkaline phosphatase level
- decreased circulating glucose level
- decreased circulating serum albumin level
- decreased circulating total protein level
- decreased eosinophil cell number
- decreased erythrocyte cell number
- decreased heart weight
- decreased hematocrit
- decreased hemoglobin content
- decreased lymphocyte cell number
- decreased mean corpuscular hemoglobin
- decreased mean corpuscular hemoglobin concentration
- enlarged lymph nodes
- hypoactivity
- improved glucose tolerance
- increased circulating phosphate level
- increased heart rate
- increased neutrophil cell number
- short tibia
- abnormal B cell physiology
- abnormal T cell activation
- abnormal T cell morphology
- abnormal T cell physiology
- abnormal circulating HDL cholesterol level
- abnormal circulating glucose level
- abnormal circulating phosphate level
- abnormal circulating serum albumin level
- abnormal circulating total protein level
- abnormal heart rate
- abnormal induced morbidity/mortality
- abnormal locomotor activation
- abnormal lymph organ size
- abnormal regulatory T cell physiology
- abnormal salivary gland duct morphology
- abnormal salivary gland morphology
- abnormal tibia morphology
- anemia
- cachexia
- colitis
- decreased body size
- decreased salivation
- diarrhea
- enlarged spleen
- hemolytic anemia
- increased IgA level
- increased IgG level
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased lymphocyte cell number
- increased memory T cell number
- lacrimal gland inflammation
- large intestinal inflammation
- lung inflammation
- lymphoid hyperplasia
- premature death
- salivary gland inflammation
role in cell
- growth
- proliferation
- differentiation
- apoptosis
- expression in
- quantity
- activation
- cell death
- survival
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- plasma membrane extracellular face
- apical membrane
- perinuclear space
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il2ra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-2-mediated signaling pathway
- negative regulation of inflammatory response
- cell surface receptor signaling pathway
- positive regulation of activated T cell proliferation
- regulation of T cell tolerance induction
- activation-induced cell death of T cells
- inflammatory response
- immune response
- Notch signaling pathway
- inflammatory response to antigenic stimulus
- regulation of T cell homeostatic proliferation
- negative regulation of T cell proliferation
- positive regulation of T cell differentiation
- apoptotic process
- regulation of CD4-positive, alpha-beta T cell proliferation
- activated T cell proliferation
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- interleukin-2 receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-2 receptor activity
- protein binding
- interleukin-2 binding